Germ cell transport across the seminiferous epithelium during spermatogenesis

Xiang Xiao, Dolores D. Mruk, Chris K C WONG, C. Yan Cheng

Research output: Contribution to journalReview articlepeer-review

67 Citations (Scopus)

Abstract

Transport of germ cells across the seminiferous epithelium is crucial to spermatogenesis. Its disruption causes infertility. Signaling molecules, such as focal adhesion kinase, c-Yes, c-Src, and intercellular adhesion molecules 1 and 2, are involved in these events by regulating actin-based cytoskeleton via their action on actin-regulating proteins, endocytic vesicle-mediated protein trafficking, and adhesion protein complexes. We critically evaluate these findings and provide a hypothetical framework that regulates these events.

Original languageEnglish
Pages (from-to)286-298
Number of pages13
JournalPhysiology
Volume29
Issue number4
DOIs
Publication statusPublished - 1 Jul 2014

Scopus Subject Areas

  • Physiology

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