@article{7b97ad2caab745ec81a22c8c0972f805,
title = "Gd (III) DOTA-Functionalized Phthalocyanine Nanodots for Magnetic Resonance Imaging and Photothermal/Photodynamic Therapy",
abstract = "The development of organic nanoagents that integrate diagnosis and therapy has gained considerable attention over the last decades. Here, phthalocyanine-based nanodots (ZnPc-NDs) are developed through a facile hydrothermal method. The self-aggregation of molecules in nanostructures facilitates the fluorescence quenching and nonradiative heat generation. Accordingly, ZnPc-NDs display the photodynamic and photothermal effect simultaneously upon near-infrared laser irradiation. To endow ZnPc-NDs with the diagnostic function, the surface of nanodots is functionalized with Gd(III) chelates to yield ZnPc-Gd, providing the magnetic resonance performances. The biocompatibility and high photocytoxicity of ZnPc-Gd toward HeLa cells are verified through the cell counting kit-8 method. Due to the presence of paramagnetic metal, ZnPc-Gd exhibits a distinct magnetic resonance signal in vitro and in vivo. Upon irradiation with a 808 nm laser, ZnPc-Gd can efficiently inhibit the growth of tumors with minor side effects. Thus, the as-prepared ZnPc-Gd can be utilized as a promising nanoagent for magnetic resonance imaging-guided cancer phototherapy.",
keywords = "MRI, nanoagents, phothermal therapy, photodynamic therapy, phthalocyanine",
author = "Fengshou Wu and Jingwen Chen and Haolan Li and Cheng Li and Han Wang and Genyan Liu and Xiaogang Luo and Xunjin Zhu",
note = "Funding Information: This work was supported by the National Natural Science Foundation of China (NSFC) (grant no. 21601142), and outstanding young and middle-aged Scientific Innovation Team of Colleges and Universities of Hubei Province: ?Biomass chemical technologies and materials? (grant no. T201908). X.Z. thanks the financial support from Innovation and Technology Commission (UIM/373) and the Inter-institutional Collaborative Research Scheme (RC-ICRS-18-19-01A), and the Interdisciplinary Research Matching Scheme (RC-IRMS/16/17/02CHEM). Funding Information: This work was supported by the National Natural Science Foundation of China (NSFC) (grant no. 21601142), and outstanding young and middle‐aged Scientific Innovation Team of Colleges and Universities of Hubei Province: “Biomass chemical technologies and materials” (grant no. T201908). X.Z. thanks the financial support from Innovation and Technology Commission (UIM/373) and the Inter‐institutional Collaborative Research Scheme (RC‐ICRS‐18‐19‐01A), and the Interdisciplinary Research Matching Scheme (RC‐IRMS/16/17/02CHEM). ",
year = "2020",
month = oct,
day = "8",
doi = "10.1002/admi.202000713",
language = "English",
volume = "7",
journal = "Advanced Materials Interfaces",
issn = "2196-7350",
publisher = "John Wiley & Sons Ltd.",
number = "19",
}