Gd (III) DOTA-Functionalized Phthalocyanine Nanodots for Magnetic Resonance Imaging and Photothermal/Photodynamic Therapy

Fengshou Wu*, Jingwen Chen, Haolan Li, Cheng Li, Han Wang, Genyan Liu, Xiaogang Luo, Xunjin ZHU

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The development of organic nanoagents that integrate diagnosis and therapy has gained considerable attention over the last decades. Here, phthalocyanine-based nanodots (ZnPc-NDs) are developed through a facile hydrothermal method. The self-aggregation of molecules in nanostructures facilitates the fluorescence quenching and nonradiative heat generation. Accordingly, ZnPc-NDs display the photodynamic and photothermal effect simultaneously upon near-infrared laser irradiation. To endow ZnPc-NDs with the diagnostic function, the surface of nanodots is functionalized with Gd(III) chelates to yield ZnPc-Gd, providing the magnetic resonance performances. The biocompatibility and high photocytoxicity of ZnPc-Gd toward HeLa cells are verified through the cell counting kit-8 method. Due to the presence of paramagnetic metal, ZnPc-Gd exhibits a distinct magnetic resonance signal in vitro and in vivo. Upon irradiation with a 808 nm laser, ZnPc-Gd can efficiently inhibit the growth of tumors with minor side effects. Thus, the as-prepared ZnPc-Gd can be utilized as a promising nanoagent for magnetic resonance imaging-guided cancer phototherapy.

Original languageEnglish
Article number2000713
JournalAdvanced Materials Interfaces
Volume7
Issue number19
DOIs
Publication statusPublished - 1 Oct 2020

Scopus Subject Areas

  • Mechanics of Materials
  • Mechanical Engineering

User-Defined Keywords

  • MRI
  • nanoagents
  • phothermal therapy
  • photodynamic therapy
  • phthalocyanine

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