Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes

Jie Pan; Bethany I. Harriss; Chi Fai Chan; Lijun Jiang; Tik Hung Tsoi; Nicholas J. Long; Wing Tak Wong; Wai Kwok Wong; Ka Leung Wong

doi:10.1021/acs.inorgchem.6b01159

Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes

Jie Pan, Bethany I. Harriss, Chi Fai Chan, Lijun Jiang, Tik Hung Tsoi, Nicholas J. Long^*, Wing Tak Wong, Wai Kwok Wong^*, Ka Leung Wong^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

13 Citations (Scopus)

Abstract

A water-soluble bimetallic normal (“cold”) and radiochemical (“hot”) gallium–porphyrin–ruthenium–bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields. ⁶⁸GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.

Original language	English
Pages (from-to)	6839-6841
Number of pages	3
Journal	Inorganic Chemistry
Volume	55
Issue number	14
Early online date	29 Jun 2016
DOIs	https://doi.org/10.1021/acs.inorgchem.6b01159
Publication status	Published - 18 Jul 2016

Scopus Subject Areas

Physical and Theoretical Chemistry
Inorganic Chemistry

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title = "Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes",

abstract = "A water-soluble bimetallic normal (“cold”) and radiochemical (“hot”) gallium–porphyrin–ruthenium–bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields. 68GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.",

author = "Jie Pan and Harriss, {Bethany I.} and Chan, {Chi Fai} and Lijun Jiang and Tsoi, {Tik Hung} and Long, {Nicholas J.} and Wong, {Wing Tak} and Wong, {Wai Kwok} and Wong, {Ka Leung}",

note = "Funding Information: This work was supported by the HKBU and HKPolyU Joint Research Programme (RC-ICRS/15-16/02F-WKL), Hong Kong Research Grant Council (203013), and a Royal Society International Exchange Grant. Publisher copyright: {\textcopyright} 2016 American Chemical Society",

year = "2016",

month = jul,

day = "18",

doi = "10.1021/acs.inorgchem.6b01159",

language = "English",

volume = "55",

pages = "6839--6841",

journal = "Inorganic Chemistry",

issn = "0020-1669",

publisher = "American Chemical Society",

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T1 - Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes

AU - Pan, Jie

AU - Harriss, Bethany I.

AU - Chan, Chi Fai

AU - Jiang, Lijun

AU - Tsoi, Tik Hung

AU - Long, Nicholas J.

AU - Wong, Wing Tak

AU - Wong, Wai Kwok

AU - Wong, Ka Leung

N1 - Funding Information: This work was supported by the HKBU and HKPolyU Joint Research Programme (RC-ICRS/15-16/02F-WKL), Hong Kong Research Grant Council (203013), and a Royal Society International Exchange Grant. Publisher copyright: © 2016 American Chemical Society

PY - 2016/7/18

Y1 - 2016/7/18

N2 - A water-soluble bimetallic normal (“cold”) and radiochemical (“hot”) gallium–porphyrin–ruthenium–bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields. 68GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.

AB - A water-soluble bimetallic normal (“cold”) and radiochemical (“hot”) gallium–porphyrin–ruthenium–bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields. 68GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.

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U2 - 10.1021/acs.inorgchem.6b01159

DO - 10.1021/acs.inorgchem.6b01159

M3 - Journal article

C2 - 27355871

AN - SCOPUS:84978709021

SN - 0020-1669

VL - 55

SP - 6839

EP - 6841

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 14

ER -

Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes

Abstract

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