Gadolinium and platinum in tandem: Real-time multi-modal monitoring of drug delivery by mri and fluorescence imaging

Hongguang Li, Bethany I. Harriss, Alkystis Phinikaridou, Sara Lacerda, Gregory Ramniceanu, Bich Thuy Doan, Ka Lok Ho, Chi Fai Chan, Wai Sum Lo, René M. Botnar, Rongfeng Lan, Cyrille Richard, Ga Lai Law, Nicholas J. Long, Ka-Leung WONG*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

A novel dual-imaging cisplatin-carrying molecular cargo capable of performing simultaneous optical and MR imaging is reported herein. This long-lasting MRI contrast agent (r1 relaxivity of 23.4 mM-1s-1 at 3T, 25o C) is a photo-activated cisplatin prodrug (PtGdL) which enables real-time monitoring of anti-cancer efficacy. PtGdL is a model for monitoring the drug delivery and anti-cancer efficacy by MRI with a much longer retention time (24 hours) in several organs such as renal cortex and spleen than GdDOTA and its motif control GdL. Upon complete release of cisplatin, all PtGdL is converted to GdL enabling subsequent MRI analyses of therapy efficacy within its reasonably short clearance time of 4 hours. There is also responsive fluorescence enhancement for monitoring by photon-excitation.

Original languageEnglish
Pages (from-to)186-195
Number of pages10
JournalNanotheranostics
Volume1
Issue number2
DOIs
Publication statusPublished - 2017

Scopus Subject Areas

  • Biotechnology
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

User-Defined Keywords

  • Cisplatin
  • Drug delivery
  • Fluorescence imaging
  • MRI
  • Multi-modal
  • Prodrug

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