Further Daphniphyllum alkaloids from the leaves of Daphniphyllum macropodum Miq

Five new polycyclic Daphniphyllum alkaloids, macropodumines F (1) and G (2), 17-oxoyuzurimine (3), and macropodumines H (4) and I (5), were isolated from the leaves of D. macropodum MIQ., collected in Sichuan Province, China. The structures and relative configurations of the new compounds - as well as of four known, related alkaloids - were elucidated on the basis of in-depth spectroscopic and mass-spectrometric analyses, by chemical derivatization, and by comparison of spectroscopic data with those of known compounds.