Functional polymorphisms of the CCL2 and MBL genes cumulatively increase susceptibility to severe acute respiratory syndrome coronavirus infection

Xinyi Tu, Wai Po Chong, Yun Zhai, Hongxing Zhang, Fang Zhang, Shixin Wang, Wei Liu, Maoti Wei, Nora Ho On Siu, Hao Yang, Wanling Yang, Wuchun Cao, Yu Lung Lau*, Fuchu He*, Gangqiao Zhou*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

73 Citations (Scopus)

Abstract

Objectives: To assess associations between the functional polymorphisms G-2518A at the chemokine (C–C motif) ligand 2 gene (CCL2) and mannose binding lectin (MBL) codon 54 variant (A/B) and susceptibility to SARS.

Methods: We genotyped the CCL2 G-2518A and MBL codon 54 variant (A/B) in 4 case–control populations of Chinese descent, totally consisting of 932 patients with SARS and 982 control subjects.

Results: Both the high-CCL2-producing GG genotype and the low-MBL-producing B allele were consistently associated with increased risks of SARS-CoV infection in all 4 case–control populations (joint P = 1.6 × 10−4 and 4.9 × 10−8, for CCL2 and MBL respectively), with no interaction between polymorphisms could be detected. Furthermore, all the 4 case–control studies demonstrated a cumulative effect on risk of SARS-CoV infection for the combination of polymorphisms (joint P = 1.3 × 10−10). However, tests using the area under the curve (AUC) indicated that at this stage, the polymorphisms were unlikely to be appropriate for risk prediction testing because of low AUC values (all <66%). Additionally, no association was observed between the polymorphisms and severity of SARS.

Conclusions: The CCL2 G-2518A and MBL codon 54 variant have a significantly cumulative effect on increased risk of SARS-CoV infection.
Original languageEnglish
Pages (from-to)101-109
Number of pages9
JournalJournal of Infection
Volume71
Issue number1
DOIs
Publication statusPublished - Jul 2015

User-Defined Keywords

  • CCL2
  • MBL
  • Severe acute respiratory syndrome
  • Polymorphism
  • Susceptibility

Fingerprint

Dive into the research topics of 'Functional polymorphisms of the CCL2 and MBL genes cumulatively increase susceptibility to severe acute respiratory syndrome coronavirus infection'. Together they form a unique fingerprint.

Cite this