Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer

Yao Chen; Weili Long; Liqiong Yang; Yueshui Zhao; Xu Wu; Mingxing Li; Fukuan Du; Yu Chen; Zhihui Yang; Qinglian Wen; Tao Yi; Zhangang Xiao; Jing Shen

doi:10.3389/fonc.2021.777374

Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer

Yao Chen, Weili Long, Liqiong Yang, Yueshui Zhao, Xu Wu, Mingxing Li, Fukuan Du, Yu Chen, Zhihui Yang, Qinglian Wen, Tao Yi, Zhangang Xiao^*, Jing Shen^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

Gastrointestinal cancer is by far the most common malignancy and the most common cause of cancer-related deaths worldwide. Recent studies have shown that long non-coding RNAs (lncRNAs) play an important role in the epigenetic regulation of cancer cells and regulate tumor progression by affecting chromatin modifications, gene transcription, translation, and sponge to miRNAs. In particular, lncRNA has recently been found to possess open reading frame (ORF), which can encode functional small peptides or proteins. These peptides interact with its targets to regulate transcription or the signal axis, thus promoting or inhibiting the occurrence and development of tumors. In this review, we summarize the involvement of lncRNAs and the function of lncRNAs encoded small peptides in gastrointestinal cancer.

Original language	English
Article number	777374
Number of pages	12
Journal	Frontiers in Oncology
Volume	11
DOIs	https://doi.org/10.3389/fonc.2021.777374
Publication status	Published - 23 Nov 2021

User-Defined Keywords

function
gastrointestinal cancer
long non-coding RNA (lncRNA)
ORF
small peptide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fonc.2021.777374

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title = "Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer",

abstract = "Gastrointestinal cancer is by far the most common malignancy and the most common cause of cancer-related deaths worldwide. Recent studies have shown that long non-coding RNAs (lncRNAs) play an important role in the epigenetic regulation of cancer cells and regulate tumor progression by affecting chromatin modifications, gene transcription, translation, and sponge to miRNAs. In particular, lncRNA has recently been found to possess open reading frame (ORF), which can encode functional small peptides or proteins. These peptides interact with its targets to regulate transcription or the signal axis, thus promoting or inhibiting the occurrence and development of tumors. In this review, we summarize the involvement of lncRNAs and the function of lncRNAs encoded small peptides in gastrointestinal cancer.",

keywords = "function, gastrointestinal cancer, long non-coding RNA (lncRNA), ORF, small peptide",

author = "Yao Chen and Weili Long and Liqiong Yang and Yueshui Zhao and Xu Wu and Mingxing Li and Fukuan Du and Yu Chen and Zhihui Yang and Qinglian Wen and Tao Yi and Zhangang Xiao and Jing Shen",

note = "Funding Information: This work was supported by National Natural Science Foundation of China (No. 81972643, No. 82172962), Sichuan Science and Technology Project (2021YJ0201) and Luxian People{\textquoteright}s Government and Southwest Medical University Scientific and Technological Achievements Transfer and Transformation Strategic Cooperation Project (2019LXXNYKD-07). Publisher Copyright: Copyright {\textcopyright} 2021 Chen, Long, Yang, Zhao, Wu, Li, Du, Chen, Yang, Wen, Yi, Xiao and Shen.",

year = "2021",

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day = "23",

doi = "10.3389/fonc.2021.777374",

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T1 - Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer

AU - Chen, Yao

AU - Long, Weili

AU - Yang, Liqiong

AU - Zhao, Yueshui

AU - Wu, Xu

AU - Li, Mingxing

AU - Du, Fukuan

AU - Chen, Yu

AU - Yang, Zhihui

AU - Wen, Qinglian

AU - Yi, Tao

AU - Xiao, Zhangang

AU - Shen, Jing

N1 - Funding Information: This work was supported by National Natural Science Foundation of China (No. 81972643, No. 82172962), Sichuan Science and Technology Project (2021YJ0201) and Luxian People’s Government and Southwest Medical University Scientific and Technological Achievements Transfer and Transformation Strategic Cooperation Project (2019LXXNYKD-07). Publisher Copyright: Copyright © 2021 Chen, Long, Yang, Zhao, Wu, Li, Du, Chen, Yang, Wen, Yi, Xiao and Shen.

PY - 2021/11/23

Y1 - 2021/11/23

N2 - Gastrointestinal cancer is by far the most common malignancy and the most common cause of cancer-related deaths worldwide. Recent studies have shown that long non-coding RNAs (lncRNAs) play an important role in the epigenetic regulation of cancer cells and regulate tumor progression by affecting chromatin modifications, gene transcription, translation, and sponge to miRNAs. In particular, lncRNA has recently been found to possess open reading frame (ORF), which can encode functional small peptides or proteins. These peptides interact with its targets to regulate transcription or the signal axis, thus promoting or inhibiting the occurrence and development of tumors. In this review, we summarize the involvement of lncRNAs and the function of lncRNAs encoded small peptides in gastrointestinal cancer.

AB - Gastrointestinal cancer is by far the most common malignancy and the most common cause of cancer-related deaths worldwide. Recent studies have shown that long non-coding RNAs (lncRNAs) play an important role in the epigenetic regulation of cancer cells and regulate tumor progression by affecting chromatin modifications, gene transcription, translation, and sponge to miRNAs. In particular, lncRNA has recently been found to possess open reading frame (ORF), which can encode functional small peptides or proteins. These peptides interact with its targets to regulate transcription or the signal axis, thus promoting or inhibiting the occurrence and development of tumors. In this review, we summarize the involvement of lncRNAs and the function of lncRNAs encoded small peptides in gastrointestinal cancer.

KW - function

KW - gastrointestinal cancer

KW - long non-coding RNA (lncRNA)

KW - ORF

KW - small peptide

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DO - 10.3389/fonc.2021.777374

M3 - Review article

AN - SCOPUS:85120859471

SN - 2234-943X

VL - 11

JO - Frontiers in Oncology

JF - Frontiers in Oncology

M1 - 777374

ER -

Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer

Abstract

User-Defined Keywords

UN SDGs

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