Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer

Yao Chen, Weili Long, Liqiong Yang, Yueshui Zhao, Xu Wu, Mingxing Li, Fukuan Du, Yu Chen, Zhihui Yang, Qinglian Wen, Tao Yi, Zhangang Xiao*, Jing Shen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)


Gastrointestinal cancer is by far the most common malignancy and the most common cause of cancer-related deaths worldwide. Recent studies have shown that long non-coding RNAs (lncRNAs) play an important role in the epigenetic regulation of cancer cells and regulate tumor progression by affecting chromatin modifications, gene transcription, translation, and sponge to miRNAs. In particular, lncRNA has recently been found to possess open reading frame (ORF), which can encode functional small peptides or proteins. These peptides interact with its targets to regulate transcription or the signal axis, thus promoting or inhibiting the occurrence and development of tumors. In this review, we summarize the involvement of lncRNAs and the function of lncRNAs encoded small peptides in gastrointestinal cancer.

Original languageEnglish
Article number777374
Number of pages12
JournalFrontiers in Oncology
Publication statusPublished - 23 Nov 2021

Scopus Subject Areas

  • Oncology
  • Cancer Research

User-Defined Keywords

  • function
  • gastrointestinal cancer
  • long non-coding RNA (lncRNA)
  • ORF
  • small peptide


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