Fructus Broussonetae extract improves cognitive function and endoplasmic reticulum stress in Alzheimer's disease models

Yinghong Li, Li Hu, Zhengzhi Wu*, Zhiling YU, Meiqun Cao, Kehuan Sun, Yu Jin, Anmin Wu, Andrew C.J. Huang

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

2 Citations (Scopus)

Abstract

This study investigated the effects and possible targets of Fructus Broussonetiae extract, a traditional Chinese medicinal herb, on a model of Alzheimer's disease induced by beta-amyloid peptide 25-35 and D-galactose. The results revealed that intragastric administration of Fructus Broussonetiae significantly increased the expression of immunoglobulin-binding protein, a key factor in the endoplasmic reticulum stress-signaling pathway in rat hippocampus. In contrast, the treatment significantly decreased expression levels of PKR-like endoplasmic reticulum kinase and C/EBP homologous protein, and substantially improved learning, memory and spatial recognition dysfunction in rats. This evidence indicates that Fructus Broussonetiae extract improves spatial learning and memory abilities in rats by affecting the regulation of hippocampal endoplasmic reticulum stress and activation of the apoptosis pathway.

Original languageEnglish
Pages (from-to)2325-2331
Number of pages7
JournalNeural Regeneration Research
Volume6
Issue number30
DOIs
Publication statusPublished - 2011

Scopus Subject Areas

  • Developmental Neuroscience

User-Defined Keywords

  • Alzheimer's disease
  • Beta-amyloid peptide 25-35
  • D-galactose
  • Endoplasmic reticulum stress
  • Fructus Broussonetiae extract
  • Neural regeneration
  • Recognition

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