From primordial germ cells to spermatids in Caenorhabditis elegans

Xiangchuan Wang, Boyi Hu, Zhongying Zhao, Yu Chung Tse*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Development of a syncytial germline for gamete formation requires complex regulation of cytokinesis and cytoplasmic remodeling. Recently, several uncovered cellular events have been investigated in the Caenorhabditis elegans (C. elegans) germline. In these cellular processes, the factors involved in contractility are highly conserved with those of mitosis and meiosis. However, the underlying regulatory mechanisms are far more complicated than previously thought, likely due to the single syncytial germline structure. In this review, we highlight how the proteins involved in contractility ensure faithful cell division in different cellular contexts and how they contribute to maintaining intercellular bridge stability. In addition, we discuss the current understanding of the cellular events of cytokinesis and cytoplasmic remodeling during the development of the C. elegans germline, including progenitor germ cells, germ cells, and spermatocytes. Comparisons are made with relevant systems in Drosophila melanogaster (D. melanogaster) and other animal models.

Original languageEnglish
JournalSeminars in Cell and Developmental Biology
DOIs
Publication statusE-pub ahead of print - 17 Dec 2021

Scopus Subject Areas

  • Developmental Biology
  • Cell Biology

User-Defined Keywords

  • Cytokinesis
  • Cytoplasmic remodeling
  • Germline
  • Primordial germ cells
  • Spermatogenesis

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