TY - JOUR
T1 - From primordial germ cells to spermatids in Caenorhabditis elegans
AU - Wang, Xiangchuan
AU - Hu, Boyi
AU - Zhao, Zhongying
AU - Tse, Yu Chung
N1 - Funding Information:
We thank Andy Loria for help with editing. This work was financially supported by the National Natural Science Foundation of China (Grant No. 31671409 ) and Natural Science Foundation of Guangdong Province of China (Grant No. 2020A1515010742 ) to Y.C.T.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2022/7
Y1 - 2022/7
N2 - Development of a syncytial germline for gamete formation requires complex regulation of cytokinesis and cytoplasmic remodeling. Recently, several uncovered cellular events have been investigated in the Caenorhabditis elegans (C. elegans) germline. In these cellular processes, the factors involved in contractility are highly conserved with those of mitosis and meiosis. However, the underlying regulatory mechanisms are far more complicated than previously thought, likely due to the single syncytial germline structure. In this review, we highlight how the proteins involved in contractility ensure faithful cell division in different cellular contexts and how they contribute to maintaining intercellular bridge stability. In addition, we discuss the current understanding of the cellular events of cytokinesis and cytoplasmic remodeling during the development of the C. elegans germline, including progenitor germ cells, germ cells, and spermatocytes. Comparisons are made with relevant systems in Drosophila melanogaster (D. melanogaster) and other animal models.
AB - Development of a syncytial germline for gamete formation requires complex regulation of cytokinesis and cytoplasmic remodeling. Recently, several uncovered cellular events have been investigated in the Caenorhabditis elegans (C. elegans) germline. In these cellular processes, the factors involved in contractility are highly conserved with those of mitosis and meiosis. However, the underlying regulatory mechanisms are far more complicated than previously thought, likely due to the single syncytial germline structure. In this review, we highlight how the proteins involved in contractility ensure faithful cell division in different cellular contexts and how they contribute to maintaining intercellular bridge stability. In addition, we discuss the current understanding of the cellular events of cytokinesis and cytoplasmic remodeling during the development of the C. elegans germline, including progenitor germ cells, germ cells, and spermatocytes. Comparisons are made with relevant systems in Drosophila melanogaster (D. melanogaster) and other animal models.
KW - Cytokinesis
KW - Cytoplasmic remodeling
KW - Germline
KW - Primordial germ cells
KW - Spermatogenesis
UR - http://www.scopus.com/inward/record.url?scp=85121360158&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2021.12.005
DO - 10.1016/j.semcdb.2021.12.005
M3 - Review article
AN - SCOPUS:85121360158
SN - 1084-9521
VL - 127
SP - 110
EP - 120
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
ER -