Formins: Actin nucleators that regulate cytoskeletal dynamics during spermatogenesis

Nan Li, Dolores D. Mruk, Elizabeth I. Tang, Chris K C WONG, Will M. Lee, Bruno Silvestrini, C. Yan Cheng*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

9 Citations (Scopus)


Formins are a growing class of actin nucleation proteins that promote the polymerization of actin microfilaments, forming long stretches of actin microfilaments to confer actin filament bundling in mammalian cells. As such, microfilament bundles can be formed in specific cellular domains, in particular in motile mammalian cells, such as filopodia. Since ectoplasmic specialization (ES), a testis-specific adherens junction (AJ), at the Sertoli cell-cell and Sertolispermatid interface is constituted by arrays of actin microfilament bundles, it is likely that formins are playing a significant physiological role on the homeostasis of ES during the epithelial cycle of spermatogenesis. In this Commentary, we provide a timely discussion on formin 1 which was recently shown to be a crucial regulator of actin microfilaments at the ES in the rat testis (Li N et al. Endocrinology, 2015, in press; DOI: 10.1210/en.2015-1161, PMID:25901598). We also highlight research that is needed to unravel the functional significance of formins in spermatogenesis.

Original languageEnglish
Article numbere1066476
Pages (from-to)1-9
Number of pages9
Issue number2
Publication statusPublished - 1 Jan 2015

Scopus Subject Areas

  • Reproductive Medicine

User-Defined Keywords

  • Actin nucleator
  • Cytoskeleton
  • F-actin
  • Formin 1
  • Formins
  • Seminiferous epithelial cycle
  • Spermatogenesis
  • Testis


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