Formal Synthesis of (+)-Phomactin A

Junrong Huang, Wenli Bao, Shuangping Huang, Wei Yang, Lizhi Zhu, Guangyan Du*, Chi Sing Lee*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

14 Citations (Scopus)


A concise formal synthesis of (+)-phomactin A has been achieved. The key features of this synthetic strategy involve a one-pot Prins/Conia-ene cyclization protocol for the construction of the highly functionalized 1-oxadeclin core (AB ring) and a late-stage direct γ-hydroxylation of enone for the installation of the C ring.

Original languageEnglish
Pages (from-to)7466-7469
Number of pages4
JournalOrganic Letters
Issue number23
Publication statusPublished - 7 Dec 2018

Scopus Subject Areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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