Keyphrases
Structure-activity Relationship
100%
P-glycoprotein (P-gp)
100%
Multidrug Resistance
100%
Homodimer
100%
Flavonoid Monomer
100%
Flavonoids
80%
Paclitaxel
40%
Small Molecule Libraries
40%
Bulky Substituents
40%
Binding Site
20%
Methyl
20%
Cytotoxicity
20%
Cytotoxic Effect
20%
IC50 Value
20%
Cancer Drugs
20%
Ethyl
20%
Doxorubicin
20%
Parent Compounds
20%
Verapamil
20%
Overexpressing
20%
Ethylene Glycol
20%
Breast Cancer Cells
20%
Multidrug-resistant
20%
Vinblastine
20%
Leukemic Cells
20%
C-3 Position
20%
C6 Position
20%
Methyl Groups
20%
Apigenin
20%
C7 Position
20%
Micromolar Concentration
20%
Cell Resistance
20%
Drug Accumulation
20%
Hydroxy Group
20%
Steric Bulk
20%
Human Breast Cancer Cell Lines
20%
Resistant Breast Cancer
20%
Paclitaxel Resistance
20%
ABCB1 Protein
20%
Modulatory Activity
20%
Pharmacology, Toxicology and Pharmaceutical Science
Dimer
100%
Flavonoid
100%
Multidrug Resistance
100%
P-Glycoprotein
100%
Homodimer
62%
Paclitaxel
37%
Heterodimer
37%
Cytotoxicity
25%
Breast Cancer
25%
Binding Site
12%
Malignant Neoplasm
12%
IC50
12%
Doxorubicin
12%
Verapamil
12%
Vinblastine
12%
Hydroxyl Group
12%
Methyl Group
12%
Apigenin
12%
Vincristine
12%
Ethylene Glycol
12%
Chemistry
dimer
100%
Flavonoid
100%
Glycoprotein
100%
Multiple Drug Resistance
100%
Homodimer
62%
Paclitaxel
37%
Heterodimer
37%
Methyl Group
25%
Binding Site
12%
IC50
12%
Ethyl Group
12%
Doxorubicin
12%
Ethylene Glycol
12%
Hydroxyl Group
12%
Verapamil
12%
Apigenin
12%
Vincristine
12%
Cancer Drug
12%