Flavidanolides A and B from Isodon flavidus

Jiang-Hai Ye, Guo-Yong Luo, Chen-Liang Zhao, Zheng-Ming Liang, Jin-Huai Wei, Ya-Hua Liu, Kang He, Lu-Tai Pan, Jing-Jie Zhang, Juan Zou*, Hong-Jie Zhang*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

1 Citation (Scopus)


A phytochemical investigation on Isodon flavidus led to the isolation of flavidanolide A (1), a rearranged diterpenoid featuring a six/seven/five-membered tricyclic skeleton, together with flavidanolide B (2), an uncommon heterodimeric diterpenoid consisting of a norabietane and a seco-isopimarane monomeric units. Their structures were elucidated by extensive spectroscopic data and single-crystal X-ray diffraction analyses. Their plausible biosynthetic routes were also proposed. In the bioassay, flavidanolide B was found to exhibit good inhibitory effect against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells comparable to positive control pyrrolidinedithiocarbamate ammonium (PDTC), which provided evidence for the medicinal value of I. flavidus as a folk medicine for treating inflammatory diseases.

Original languageEnglish
Article number108621
JournalChinese Chemical Letters
Issue number9
Early online date30 May 2023
Publication statusPublished - Sept 2023

Scopus Subject Areas

  • Chemistry(all)

User-Defined Keywords

  • Antiinflammatory effects
  • Heterodimeric diterpenoid
  • Isodon flavidus
  • Plausible biosynthetic pathway
  • Rearranged six/seven/five-membered skeleton


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