TY - JOUR
T1 - Flavidanolides A and B from Isodon flavidus
AU - Ye, Jiang-Hai
AU - Luo, Guo-Yong
AU - Zhao, Chen-Liang
AU - Liang, Zheng-Ming
AU - Wei, Jin-Huai
AU - Liu, Ya-Hua
AU - He, Kang
AU - Pan, Lu-Tai
AU - Zhang, Jing-Jie
AU - Zou, Juan
AU - Zhang, Hong-Jie
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (No. 82204605 ), the National Natural Science Foundation of China (No. 81560709 ), the Technology Fund of Guizhou Administration of Traditional Chinese Medicine (No. QZYY-2022-019 ), Science and Technology Tip-top Talent Foundation of Universities in Guizhou Province (No. Qian jiao he KY (2021) 034 ), the Research Grant Council of the Hong Kong Special Administrative Region , China (No. HKBU 12102219 ), the University Grants Committee of the Hong Kong Special Administrative Region , China (UGC Research Matching Grant Scheme, No. RMG2019_1_19 ).
Publisher Copyright:
© 2023
PY - 2023/9
Y1 - 2023/9
N2 - A phytochemical investigation on Isodon flavidus led
to the isolation of flavidanolide A (1), a rearranged diterpenoid featuring
a six/seven/five-membered tricyclic skeleton, together with flavidanolide B (2), an
uncommon heterodimeric diterpenoid consisting
of a norabietane and a seco-isopimarane
monomeric units. Their structures were elucidated by extensive spectroscopic data and
single-crystal X-ray diffraction analyses. Their plausible biosynthetic routes
were also proposed. In the bioassay, flavidanolide B was found to exhibit good
inhibitory effect against lipopolysaccharide (LPS)-induced nitric oxide (NO)
production in RAW264.7 cells comparable to positive control
pyrrolidinedithiocarbamate ammonium (PDTC), which provided evidence for the
medicinal value of I. flavidus as
a folk medicine for treating inflammatory diseases.
AB - A phytochemical investigation on Isodon flavidus led
to the isolation of flavidanolide A (1), a rearranged diterpenoid featuring
a six/seven/five-membered tricyclic skeleton, together with flavidanolide B (2), an
uncommon heterodimeric diterpenoid consisting
of a norabietane and a seco-isopimarane
monomeric units. Their structures were elucidated by extensive spectroscopic data and
single-crystal X-ray diffraction analyses. Their plausible biosynthetic routes
were also proposed. In the bioassay, flavidanolide B was found to exhibit good
inhibitory effect against lipopolysaccharide (LPS)-induced nitric oxide (NO)
production in RAW264.7 cells comparable to positive control
pyrrolidinedithiocarbamate ammonium (PDTC), which provided evidence for the
medicinal value of I. flavidus as
a folk medicine for treating inflammatory diseases.
KW - Antiinflammatory effects
KW - Heterodimeric diterpenoid
KW - Isodon flavidus
KW - Plausible biosynthetic pathway
KW - Rearranged six/seven/five-membered skeleton
UR - http://www.scopus.com/inward/record.url?scp=85163468174&partnerID=8YFLogxK
U2 - 10.1016/j.cclet.2023.108621
DO - 10.1016/j.cclet.2023.108621
M3 - Journal article
AN - SCOPUS:85163468174
SN - 1001-8417
VL - 34
JO - Chinese Chemical Letters
JF - Chinese Chemical Letters
IS - 9
M1 - 108621
ER -
