Fast uptake, water-soluble, mitochondria-specific erbium complex for a dual function molecular probe - Imaging and photodynamic therapy

Tao Zhang; Chi Fai Chan; Jianhua Hao; Ga Lai Law; Rick W K WONG; Ka-Leung WONG

doi:10.1039/c2ra22056c

Fast uptake, water-soluble, mitochondria-specific erbium complex for a dual function molecular probe - Imaging and photodynamic therapy

Tao Zhang
, Chi Fai Chan
, Jianhua Hao
, Ga Lai Law^*
, Rick W K WONG
, Ka-Leung WONG

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

31 Citations (Scopus)

Abstract

A water-soluble, mitochondria-permeable erbium(iii) complex has been designed as a responsive bi-functional probe. This may be used to induce the mild formation of singlet oxygen (Φ_Δ = 0.10) and causes local damage in cellulo when exposed to UV and near-infrared laser excitation.

Original language	English
Pages (from-to)	382-385
Number of pages	4
Journal	RSC Advances
Volume	3
Issue number	2
DOIs	https://doi.org/10.1039/c2ra22056c
Publication status	Published - 14 Jan 2013

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10.1039/c2ra22056c

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title = "Fast uptake, water-soluble, mitochondria-specific erbium complex for a dual function molecular probe - Imaging and photodynamic therapy",

abstract = "A water-soluble, mitochondria-permeable erbium(iii) complex has been designed as a responsive bi-functional probe. This may be used to induce the mild formation of singlet oxygen (ΦΔ = 0.10) and causes local damage in cellulo when exposed to UV and near-infrared laser excitation.",

author = "Tao Zhang and Chan, \{Chi Fai\} and Jianhua Hao and Law, \{Ga Lai\} and WONG, \{Rick W K\} and Ka-Leung WONG",

note = "The work described in this paper was partially supported by grants from the HKRGC (HKBU 202811) and from the Hong Kong Baptist University (KLW FRG2/11-12/003).",

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T1 - Fast uptake, water-soluble, mitochondria-specific erbium complex for a dual function molecular probe - Imaging and photodynamic therapy

AU - Zhang, Tao

AU - Chan, Chi Fai

AU - Hao, Jianhua

AU - Law, Ga Lai

AU - WONG, Rick W K

AU - WONG, Ka-Leung

N1 - The work described in this paper was partially supported by grants from the HKRGC (HKBU 202811) and from the Hong Kong Baptist University (KLW FRG2/11-12/003).

PY - 2013/1/14

Y1 - 2013/1/14

N2 - A water-soluble, mitochondria-permeable erbium(iii) complex has been designed as a responsive bi-functional probe. This may be used to induce the mild formation of singlet oxygen (ΦΔ = 0.10) and causes local damage in cellulo when exposed to UV and near-infrared laser excitation.

AB - A water-soluble, mitochondria-permeable erbium(iii) complex has been designed as a responsive bi-functional probe. This may be used to induce the mild formation of singlet oxygen (ΦΔ = 0.10) and causes local damage in cellulo when exposed to UV and near-infrared laser excitation.

UR - https://www.scopus.com/pages/publications/84870941953

U2 - 10.1039/c2ra22056c

DO - 10.1039/c2ra22056c

M3 - Journal article

AN - SCOPUS:84870941953

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EP - 385

JO - RSC Advances

JF - RSC Advances

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ER -

Fast uptake, water-soluble, mitochondria-specific erbium complex for a dual function molecular probe - Imaging and photodynamic therapy

Abstract

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