Fang-Feng-Tang's potential therapeutic agents for rheumatoid arthritis

Guang Zheng*, Ting Hao, Rong Li, Lingru Wang, Kai Cui, Cheng Lu, Aiping LYU

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingConference contributionpeer-review

Abstract

Fang-Feng-Tang is a Chinese herbal formula which is designed to treat syndrome Feng-Han-Shi-Bi for rheumatoid arthritis (RA). Although its therapeutic effects are widely accepted, its mechanism is still obscure. In this study, by integrating leading knowledge databases of associated different domains, we explored Fang-Feng-Tang's potential therapeutic agents for RA through targeted pathway hierarchies. The molecule mechanism analysis includes compositional herbal medicine, chemical compound, target protein, and pathways enriched. Target proteins are restricted with RA OMIM genes and FDA approved RA drug targets for partial validation. As a result, 8 target proteins were matched and they are UGT1A9, GNT1, UGT1, JAK3, CCR2/5, and CMKBR2/5. What's more, they are mainly involved in pathways of signal transduction, metabolism, immune system, and disease. This research demonstrates that Feng-Feng-Tang's target proteins may regulate a wide range of different systems. This might indicate that Chinese herbal formula's therapeutic effects can be demonstrated through system-level regulation rather than targeting disease specified genes or proteins.

Original languageEnglish
Title of host publicationProceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
EditorsHuiru Zheng, Xiaohua Tony Hu, Yadong Wang, Jin-Kao Hao, David Gilbert, Daniel Berrar, Kwang-Hyun Cho, Werner Dubitzky
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages235-238
Number of pages4
ISBN (Electronic)9781479956692
DOIs
Publication statusPublished - 29 Dec 2014
Event2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014 - Belfast, United Kingdom
Duration: 2 Nov 20145 Nov 2014

Publication series

NameProceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014

Conference

Conference2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
Country/TerritoryUnited Kingdom
CityBelfast
Period2/11/145/11/14

Scopus Subject Areas

  • Biomedical Engineering
  • Health Informatics

User-Defined Keywords

  • Fang-Feng-Tang
  • molecular mechanism
  • rheumatoid arthritis
  • traditional Chinese medicine

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