TY - GEN
T1 - Fang-Feng-Tang's potential therapeutic agents for rheumatoid arthritis
AU - Zheng, Guang
AU - Hao, Ting
AU - Li, Rong
AU - Wang, Lingru
AU - Cui, Kai
AU - Lu, Cheng
AU - LYU, Aiping
N1 - Publisher Copyright:
© 2014 IEEE.
PY - 2014/12/29
Y1 - 2014/12/29
N2 - Fang-Feng-Tang is a Chinese herbal formula which is designed to treat syndrome Feng-Han-Shi-Bi for rheumatoid arthritis (RA). Although its therapeutic effects are widely accepted, its mechanism is still obscure. In this study, by integrating leading knowledge databases of associated different domains, we explored Fang-Feng-Tang's potential therapeutic agents for RA through targeted pathway hierarchies. The molecule mechanism analysis includes compositional herbal medicine, chemical compound, target protein, and pathways enriched. Target proteins are restricted with RA OMIM genes and FDA approved RA drug targets for partial validation. As a result, 8 target proteins were matched and they are UGT1A9, GNT1, UGT1, JAK3, CCR2/5, and CMKBR2/5. What's more, they are mainly involved in pathways of signal transduction, metabolism, immune system, and disease. This research demonstrates that Feng-Feng-Tang's target proteins may regulate a wide range of different systems. This might indicate that Chinese herbal formula's therapeutic effects can be demonstrated through system-level regulation rather than targeting disease specified genes or proteins.
AB - Fang-Feng-Tang is a Chinese herbal formula which is designed to treat syndrome Feng-Han-Shi-Bi for rheumatoid arthritis (RA). Although its therapeutic effects are widely accepted, its mechanism is still obscure. In this study, by integrating leading knowledge databases of associated different domains, we explored Fang-Feng-Tang's potential therapeutic agents for RA through targeted pathway hierarchies. The molecule mechanism analysis includes compositional herbal medicine, chemical compound, target protein, and pathways enriched. Target proteins are restricted with RA OMIM genes and FDA approved RA drug targets for partial validation. As a result, 8 target proteins were matched and they are UGT1A9, GNT1, UGT1, JAK3, CCR2/5, and CMKBR2/5. What's more, they are mainly involved in pathways of signal transduction, metabolism, immune system, and disease. This research demonstrates that Feng-Feng-Tang's target proteins may regulate a wide range of different systems. This might indicate that Chinese herbal formula's therapeutic effects can be demonstrated through system-level regulation rather than targeting disease specified genes or proteins.
KW - Fang-Feng-Tang
KW - molecular mechanism
KW - rheumatoid arthritis
KW - traditional Chinese medicine
UR - http://www.scopus.com/inward/record.url?scp=84922794128&partnerID=8YFLogxK
U2 - 10.1109/BIBM.2014.6999366
DO - 10.1109/BIBM.2014.6999366
M3 - Conference proceeding
AN - SCOPUS:84922794128
T3 - Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
SP - 235
EP - 238
BT - Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
A2 - Zheng, Huiru Jane
A2 - Hu, Xiaohua
A2 - Berrar, Daniel
A2 - Wang, Yadong
A2 - Dubitzky, Werner
A2 - Hao, Jin-Kao
A2 - Cho, Kwang-Hyun
A2 - Gilbert, David
PB - IEEE
T2 - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
Y2 - 2 November 2014 through 5 November 2014
ER -