Facile synthesis of hollow microtubular COF as enrichment probe for quantitative detection of ultratrace quinones in mice plasma with APGC-MS/MS

Ran Wang, Wei Tong, Yijing Wu, Zhuling Chen, Zian Lin*, Zongwei Cai*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

2 Citations (Scopus)

Abstract

A hollow microtubular covalent organic framework (denoted as TatDha-COF) was synthesized by solvothermal method for the enrichment and determination of quinones. The TatDha-COF showed large specific surface area (2057 m2 g−1), good crystal structure, ordered pore size distribution (2.3 nm), stable chemical properties and good reusability. Accordingly, a simple and efficient method based on dispersive solid-phase extraction (d-SPE) and atmospheric pressure gas chromatography tandem mass spectrometry (APGC-MS/MS) was developed for the determination of quinones in complex samples. The established method demonstrated a wide liner range, good linearity (r>0.9990), high enrichment factors (EFs, 24–69-folds) and low detection limits (LODs, 0.200–30.0 pg L−1, S/N≥3). On this basis, the suggested method was successfully applied to sensitively detect the eight ultratrace quinones in mice plasma. Overall, the established method has provided a powerful tool for the enrichment and detection of ultratrace quinones in complex samples, presenting the promising application of TatDha-COF in sample pretreatment. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Article number72
Number of pages8
JournalMicrochimica Acta
Volume190
Issue number2
Early online date25 Jan 2023
DOIs
Publication statusPublished - Feb 2023

Scopus Subject Areas

  • Analytical Chemistry

User-Defined Keywords

  • APGC-MS/MS
  • Dispersive solid-phase extraction
  • Hollow microtubular covalent organic frameworks
  • Plasma analysis
  • Quinones

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