TY - JOUR
T1 - Facile synthesis of hollow microtubular COF as enrichment probe for quantitative detection of ultratrace quinones in mice plasma with APGC-MS/MS
AU - Wang, Ran
AU - Tong, Wei
AU - Wu, Yijing
AU - Chen, Zhuling
AU - Lin, Zian
AU - Cai, Zongwei
N1 - This work was supported by the National Natural Science Foundation of China (22036001, 91843301 and 21974021) and the Major Project of Science and Technology of Fujian Province (2020HZ06006).
Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
PY - 2023/2
Y1 - 2023/2
N2 - A hollow microtubular covalent organic framework (denoted as TatDha-COF) was synthesized by solvothermal method for the enrichment and determination of quinones. The TatDha-COF showed large specific surface area (2057 m2 g−1), good crystal structure, ordered pore size distribution (2.3 nm), stable chemical properties and good reusability. Accordingly, a simple and efficient method based on dispersive solid-phase extraction (d-SPE) and atmospheric pressure gas chromatography tandem mass spectrometry (APGC-MS/MS) was developed for the determination of quinones in complex samples. The established method demonstrated a wide liner range, good linearity (r>0.9990), high enrichment factors (EFs, 24–69-folds) and low detection limits (LODs, 0.200–30.0 pg L−1, S/N≥3). On this basis, the suggested method was successfully applied to sensitively detect the eight ultratrace quinones in mice plasma. Overall, the established method has provided a powerful tool for the enrichment and detection of ultratrace quinones in complex samples, presenting the promising application of TatDha-COF in sample pretreatment. Graphical abstract: [Figure not available: see fulltext.]
AB - A hollow microtubular covalent organic framework (denoted as TatDha-COF) was synthesized by solvothermal method for the enrichment and determination of quinones. The TatDha-COF showed large specific surface area (2057 m2 g−1), good crystal structure, ordered pore size distribution (2.3 nm), stable chemical properties and good reusability. Accordingly, a simple and efficient method based on dispersive solid-phase extraction (d-SPE) and atmospheric pressure gas chromatography tandem mass spectrometry (APGC-MS/MS) was developed for the determination of quinones in complex samples. The established method demonstrated a wide liner range, good linearity (r>0.9990), high enrichment factors (EFs, 24–69-folds) and low detection limits (LODs, 0.200–30.0 pg L−1, S/N≥3). On this basis, the suggested method was successfully applied to sensitively detect the eight ultratrace quinones in mice plasma. Overall, the established method has provided a powerful tool for the enrichment and detection of ultratrace quinones in complex samples, presenting the promising application of TatDha-COF in sample pretreatment. Graphical abstract: [Figure not available: see fulltext.]
KW - APGC-MS/MS
KW - Dispersive solid-phase extraction
KW - Hollow microtubular covalent organic frameworks
KW - Plasma analysis
KW - Quinones
UR - http://www.scopus.com/inward/record.url?scp=85146832911&partnerID=8YFLogxK
U2 - 10.1007/s00604-023-05639-9
DO - 10.1007/s00604-023-05639-9
M3 - Journal article
C2 - 36695957
AN - SCOPUS:85146832911
SN - 0026-3672
VL - 190
JO - Microchimica Acta
JF - Microchimica Acta
IS - 2
M1 - 72
ER -