Facile Preparation of Phthalocyanine-Based Nanodots for Photoacoustic Imaging and Photothermal Cancer Therapy in Vivo

Fengshou Wu*, Liangliang Yue, Kai Cheng, Jun Chen, Ka-Leung WONG, Rick W K WONG, Xunjin ZHU

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The development of near-infrared (NIR)-absorbing nanoagents for personalized multifunctional phototheranostics has attracted considerable attention in the past decade. Recently, the organic nanomaterials with good biosafety are considered as promising phototheranostic agents, while their facile synthesis remains challenging. Inspired by the preparation of carbon nanodots, we fabricate the NIR-absorbing phthalocyanine-based nanodots (ZnPc-NDs) using a facile method for multifunctional phototheranostics. The significant aggregation of phthalocyanines in nanodots induces a complete fluorescence quenching, which affords a high photothermal conversion efficiency (η = 45.7%). The ZnPc-NDs disperse very well in water media with an average diameter around 80 nm. Further conjugation of biotin on the surface of ZnPc-NDs affords tumor-targeting phthalocyanine nanodots (ZnPc-BT). The ZnPc-BT are demonstrated with favorable biocompatibility, intense photoacoustic signals, high tumor accumulation, and effective tumor suppression in vivo. This Article provides a new insight for further developing nanomedicines with imaging and therapeutic functions to treat cancers precisely and effectively.

Original languageEnglish
Pages (from-to)5230-5239
Number of pages10
JournalACS Biomaterials Science and Engineering
Volume6
Issue number9
DOIs
Publication statusPublished - 14 Sep 2020

Scopus Subject Areas

  • Biomaterials
  • Biomedical Engineering

User-Defined Keywords

  • nanodots
  • organic nanoparticles
  • photoacoustic imaging
  • photothermal therapy
  • phthalocyanine

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