TY - JOUR
T1 - Facile Preparation of Phthalocyanine-Based Nanodots for Photoacoustic Imaging and Photothermal Cancer Therapy in Vivo
AU - Wu, Fengshou
AU - Yue, Liangliang
AU - Cheng, Kai
AU - Chen, Jun
AU - Wong, Ka-Leung
AU - Wong, Rick W K
AU - Zhu, Xunjin
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (NSFC) (grant no. 21601142) and the Natural Science Foundation of Hubei Province (grant no. 2018CFB159). X.Z. is thankful for the financial support from the Innovation and Technology Commission (UIM/373) and the Interinstitutional Collaborative Research Scheme (RC-ICRS-18-19-01A), and from the Interdisciplinary Research Matching Scheme (RC-IRMS/16/17/02CHEM).
PY - 2020/9/14
Y1 - 2020/9/14
N2 - The development of near-infrared (NIR)-absorbing nanoagents for personalized multifunctional phototheranostics has attracted considerable attention in the past decade. Recently, the organic nanomaterials with good biosafety are considered as promising phototheranostic agents, while their facile synthesis remains challenging. Inspired by the preparation of carbon nanodots, we fabricate the NIR-absorbing phthalocyanine-based nanodots (ZnPc-NDs) using a facile method for multifunctional phototheranostics. The significant aggregation of phthalocyanines in nanodots induces a complete fluorescence quenching, which affords a high photothermal conversion efficiency (η = 45.7%). The ZnPc-NDs disperse very well in water media with an average diameter around 80 nm. Further conjugation of biotin on the surface of ZnPc-NDs affords tumor-targeting phthalocyanine nanodots (ZnPc-BT). The ZnPc-BT are demonstrated with favorable biocompatibility, intense photoacoustic signals, high tumor accumulation, and effective tumor suppression in vivo. This Article provides a new insight for further developing nanomedicines with imaging and therapeutic functions to treat cancers precisely and effectively.
AB - The development of near-infrared (NIR)-absorbing nanoagents for personalized multifunctional phototheranostics has attracted considerable attention in the past decade. Recently, the organic nanomaterials with good biosafety are considered as promising phototheranostic agents, while their facile synthesis remains challenging. Inspired by the preparation of carbon nanodots, we fabricate the NIR-absorbing phthalocyanine-based nanodots (ZnPc-NDs) using a facile method for multifunctional phototheranostics. The significant aggregation of phthalocyanines in nanodots induces a complete fluorescence quenching, which affords a high photothermal conversion efficiency (η = 45.7%). The ZnPc-NDs disperse very well in water media with an average diameter around 80 nm. Further conjugation of biotin on the surface of ZnPc-NDs affords tumor-targeting phthalocyanine nanodots (ZnPc-BT). The ZnPc-BT are demonstrated with favorable biocompatibility, intense photoacoustic signals, high tumor accumulation, and effective tumor suppression in vivo. This Article provides a new insight for further developing nanomedicines with imaging and therapeutic functions to treat cancers precisely and effectively.
KW - nanodots
KW - organic nanoparticles
KW - photoacoustic imaging
KW - photothermal therapy
KW - phthalocyanine
UR - http://www.scopus.com/inward/record.url?scp=85092586069&partnerID=8YFLogxK
U2 - 10.1021/acsbiomaterials.0c00684
DO - 10.1021/acsbiomaterials.0c00684
M3 - Journal article
C2 - 33455272
AN - SCOPUS:85092586069
SN - 2373-9878
VL - 6
SP - 5230
EP - 5239
JO - ACS Biomaterials Science and Engineering
JF - ACS Biomaterials Science and Engineering
IS - 9
ER -
