Extracellular vesicles as a promising platform of precision medicine in liver cancer

Keyang Xu; Qibiao Wu; Lingyun Zhao; Romario Nguyen; Fatema  Safri; William  Yang; Yikun  Xu; Yun Ye; Hiu Yee Kwan; Qiang Wang; Xiuming  Liang; Muhammad J.A.  Shiddiky; Majid E.  Warkiani; Jacob  George; Liang  Qiao; Jianfeng  Bao

doi:10.1016/j.phrs.2025.107800

Extracellular vesicles as a promising platform of precision medicine in liver cancer

Keyang Xu
, Qibiao Wu
, Lingyun Zhao
, Romario Nguyen
, Fatema Safri
, William Yang
, Yikun Xu
, Yun Ye
, Hiu Yee Kwan
, Qiang Wang
, Xiuming Liang
, Muhammad J.A. Shiddiky
, Majid E. Warkiani
, Jacob George^*
, Liang Qiao^*
, Jianfeng Bao^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

1 Citation (Scopus)

Abstract

Extracellular vesicles (EVs) are natural carriers of biological information and play pivotal roles in intercellular communication. EVs are biocompatible, have low immunogenicity, and are capable of traversing biological barriers, making them ideal tools for disease diagnosis and therapy. Despite their promising prospects, the full realization of EVs potential faces several challenges. This article aims to comprehensively review the biological and molecular features of EVs, their applications in liver cancer and possible underlying mechanisms, and the critical challenges affecting the clinical translation of EVs-based therapies in liver cancer.

Original language	English
Article number	107800
Number of pages	11
Journal	Pharmacological Research
Volume	217
Early online date	24 May 2025
DOIs	https://doi.org/10.1016/j.phrs.2025.107800
Publication status	Published - Jul 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

Extracellular vesicles (EVs)
Liver cancer
Organoids
Standardization
Therapeutic tools

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10.1016/j.phrs.2025.107800

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title = "Extracellular vesicles as a promising platform of precision medicine in liver cancer",

abstract = "Extracellular vesicles (EVs) are natural carriers of biological information and play pivotal roles in intercellular communication. EVs are biocompatible, have low immunogenicity, and are capable of traversing biological barriers, making them ideal tools for disease diagnosis and therapy. Despite their promising prospects, the full realization of EVs potential faces several challenges. This article aims to comprehensively review the biological and molecular features of EVs, their applications in liver cancer and possible underlying mechanisms, and the critical challenges affecting the clinical translation of EVs-based therapies in liver cancer.",

keywords = "Extracellular vesicles (EVs), Liver cancer, Organoids, Standardization, Therapeutic tools",

author = "Keyang Xu and Qibiao Wu and Lingyun Zhao and Romario Nguyen and Fatema Safri and William Yang and Yikun Xu and Yun Ye and Kwan, \{Hiu Yee\} and Qiang Wang and Xiuming Liang and Shiddiky, \{Muhammad J.A.\} and Warkiani, \{Majid E.\} and Jacob George and Liang Qiao and Jianfeng Bao",

note = "This study was funded by the Science and Technology Development Fund, Macau SAR (0098/2021/A2 and 0048/2023/AFJ, to QB Wu), Biomedical Enterprise Project of Hangzhou Science and Technology Bureau (2022WJC230, 2021WJCY190), the Health and Medicine Technology Project of Hangzhou, China (Z20240019) and Hangzhou {"}115{"} Outstanding Foreign Expertise Introduction Project Fund. JG and LQ are supported by the Robert W. Storr Bequest to the Sydney Medical Foundation, University of Sydney; JG is supported a National Health and Medical Research Council of Australia (NHMRC) Program Grant (APP1053206), Investigator and MRFF grants (APP2032407; NCRI000183; APP2016215; APP2010795; APP1196492) and a Cancer Institute, NSW grant (2021/ATRG2028). Publisher Copyright: {\textcopyright} 2025 The Authors.",

year = "2025",

month = jul,

doi = "10.1016/j.phrs.2025.107800",

language = "English",

volume = "217",

journal = "Pharmacological Research",

issn = "1043-6618",

publisher = "Academic Press",

}

TY - JOUR

T1 - Extracellular vesicles as a promising platform of precision medicine in liver cancer

AU - Xu, Keyang

AU - Wu, Qibiao

AU - Zhao, Lingyun

AU - Nguyen, Romario

AU - Safri, Fatema

AU - Yang, William

AU - Xu , Yikun

AU - Ye, Yun

AU - Kwan, Hiu Yee

AU - Wang, Qiang

AU - Liang, Xiuming

AU - Shiddiky, Muhammad J.A.

AU - Warkiani, Majid E.

AU - George, Jacob

AU - Qiao, Liang

AU - Bao, Jianfeng

N1 - This study was funded by the Science and Technology Development Fund, Macau SAR (0098/2021/A2 and 0048/2023/AFJ, to QB Wu), Biomedical Enterprise Project of Hangzhou Science and Technology Bureau (2022WJC230, 2021WJCY190), the Health and Medicine Technology Project of Hangzhou, China (Z20240019) and Hangzhou "115" Outstanding Foreign Expertise Introduction Project Fund. JG and LQ are supported by the Robert W. Storr Bequest to the Sydney Medical Foundation, University of Sydney; JG is supported a National Health and Medical Research Council of Australia (NHMRC) Program Grant (APP1053206), Investigator and MRFF grants (APP2032407; NCRI000183; APP2016215; APP2010795; APP1196492) and a Cancer Institute, NSW grant (2021/ATRG2028). Publisher Copyright: © 2025 The Authors.

PY - 2025/7

Y1 - 2025/7

N2 - Extracellular vesicles (EVs) are natural carriers of biological information and play pivotal roles in intercellular communication. EVs are biocompatible, have low immunogenicity, and are capable of traversing biological barriers, making them ideal tools for disease diagnosis and therapy. Despite their promising prospects, the full realization of EVs potential faces several challenges. This article aims to comprehensively review the biological and molecular features of EVs, their applications in liver cancer and possible underlying mechanisms, and the critical challenges affecting the clinical translation of EVs-based therapies in liver cancer.

AB - Extracellular vesicles (EVs) are natural carriers of biological information and play pivotal roles in intercellular communication. EVs are biocompatible, have low immunogenicity, and are capable of traversing biological barriers, making them ideal tools for disease diagnosis and therapy. Despite their promising prospects, the full realization of EVs potential faces several challenges. This article aims to comprehensively review the biological and molecular features of EVs, their applications in liver cancer and possible underlying mechanisms, and the critical challenges affecting the clinical translation of EVs-based therapies in liver cancer.

KW - Extracellular vesicles (EVs)

KW - Liver cancer

KW - Organoids

KW - Standardization

KW - Therapeutic tools

UR - https://www.scopus.com/pages/publications/105007161450

U2 - 10.1016/j.phrs.2025.107800

DO - 10.1016/j.phrs.2025.107800

M3 - Journal article

SN - 1043-6618

VL - 217

JO - Pharmacological Research

JF - Pharmacological Research

M1 - 107800

ER -

Extracellular vesicles as a promising platform of precision medicine in liver cancer

Abstract

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