@article{23611513dd5743e097e9bb8f726cb2d6,
title = "Extracellular vesicles as a promising platform of precision medicine in liver cancer",
abstract = "Extracellular vesicles (EVs) are natural carriers of biological information and play pivotal roles in intercellular communication. EVs are biocompatible, have low immunogenicity, and are capable of traversing biological barriers, making them ideal tools for disease diagnosis and therapy. Despite their promising prospects, the full realization of EVs potential faces several challenges. This article aims to comprehensively review the biological and molecular features of EVs, their applications in liver cancer and possible underlying mechanisms, and the critical challenges affecting the clinical translation of EVs-based therapies in liver cancer.",
keywords = "Extracellular vesicles (EVs), Liver cancer, Organoids, Standardization, Therapeutic tools",
author = "Keyang XU and Qibiao Wu and Lingyun Zhao and Romario Nguyen and Fatema Safri and William Yang and Yikun Xu and Yun YE and Kwan, {Hiu Yee} and Qiang Wang and Xiuming Liang and Shiddiky, {Muhammad J.A.} and Warkiani, {Majid E.} and Jacob George and Liang Qiao and Jianfeng Bao",
note = "This study was funded by the Science and Technology Development Fund, Macau SAR (0098/2021/A2 and 0048/2023/AFJ, to QB Wu), Biomedical Enterprise Project of Hangzhou Science and Technology Bureau (2022WJC230, 2021WJCY190), the Health and Medicine Technology Project of Hangzhou, China (Z20240019) and Hangzhou {"}115{"} Outstanding Foreign Expertise Introduction Project Fund. JG and LQ are supported by the Robert W. Storr Bequest to the Sydney Medical Foundation, University of Sydney; JG is supported a National Health and Medical Research Council of Australia (NHMRC) Program Grant (APP1053206), Investigator and MRFF grants (APP2032407; NCRI000183; APP2016215; APP2010795; APP1196492) and a Cancer Institute, NSW grant (2021/ATRG2028). Publisher Copyright: {\textcopyright} 2025 The Authors.",
year = "2025",
month = jul,
doi = "10.1016/j.phrs.2025.107800",
language = "English",
volume = "217",
journal = "Pharmacological Research",
issn = "1043-6618",
publisher = "Academic Press",
}
