Expression of GABA transaminase immunoreactivity in interneurons of the rat neostriatum

Kin Lam Yung*, K. H.H. Kwok, Z. G. Gao, S. Y. Choi, F. S.L. Kwok

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

12 Citations (Scopus)


Immunoreactivity for γ-aminobutyric acid transaminase (GABA-T), a degradation enzyme for GABA, was localized by immunocytochemistry in the rat neostriatum and the globus pallidus using a monoclonal antibody. Immunoreactivity for GABA-T was found primarily in interneurons and in the neuropilar elements in the neostriatum. Many of GABA-T-immunoreactive neurons were found to display parvalbumin immunoreactivity. This indicates many of the GABA-T-immunoreactive neurons are striatal GABAergic interneurons. Occasionally; GABA-T-immunoreactive glial cells were found. In the globus pallidus, many pallidal neurons also displayed GABA-T immunoreactivity and many of the immunoreactive neurons were seen to express parvalbumin immunoreactivity. Immunoreactivity for GABA-T was also detected in the neuropil of the globus pallidus. The present results indicate the GABAergic interneurons in the neostriatum and a subpopulation of pallidal neurons play an important role in metabolic degradation of GABA in the basal ganglia.

Original languageEnglish
Pages (from-to)567-572
Number of pages6
JournalNeurochemistry International
Issue number6
Publication statusPublished - 1 Dec 1998

Scopus Subject Areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

User-Defined Keywords

  • Avidin-biotin-peroxidase reaction
  • Basal ganglia
  • Immunocytochemistry
  • Immunofluorescence
  • Light microscopy


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