TY - JOUR
T1 - Exposure to benzophenones, parabens and triclosan among pregnant women in different trimesters
AU - Zhao, Hongzhi
AU - Huo, Wenqian
AU - Li, Jiufeng
AU - Ma, Xinli
AU - Xia, Wei
AU - Pang, Zhengji
AU - Xie, Mingyi
AU - Xu, Shunqing
AU - Cai, Zongwei
N1 - Funding Information:
This work was supported by National Natural Science Foundation of China (Grant numbers 21437002 and 21505111) and General Research Fund (GRF 12319716) and Collaborative Research Fund (CRF) C2014-14E from Research Grants Council (RGC) of Hong Kong, China.
PY - 2017/12/31
Y1 - 2017/12/31
N2 - Humans are potentially exposed to many environmental pollutants, many of which may cause adverse health effects, especially to pregnant women and their fetuses. In this study, 11 environmental pollutants from three different chemical classes, including benzophenones, parabens and triclosan were measured in 627 urine samples collected from 209 pregnant women to evaluate exposure and trends as a function of pregnancy stage. Methylparaben (MeP), ethylparaben, propylparaben (PrP), butylparaben, 2,4-dihydroxybenzophenone (BP-1), 2-hydroxy-4-methoxybenzophenone (BP-3) and 4-hydroxybenzophenone were detected in > 50% samples. The concentrations of BP-1 and BP-3 (Spearman's r = 0.57, p < 0.01) and those of MeP and PrP (Spearman's r = 0.68, p < 0.01) were found to be correlated. The urinary concentrations of BP-1 and BP-3 in the first trimester were significantly higher than those in the second or third trimester (Mann-Whitney U test, p < 0.05). These findings provide valuable information for improving the prediction of maternal exposure to these emerging pollutants and for assessing their potential health risks to the mother as well as the offspring.
AB - Humans are potentially exposed to many environmental pollutants, many of which may cause adverse health effects, especially to pregnant women and their fetuses. In this study, 11 environmental pollutants from three different chemical classes, including benzophenones, parabens and triclosan were measured in 627 urine samples collected from 209 pregnant women to evaluate exposure and trends as a function of pregnancy stage. Methylparaben (MeP), ethylparaben, propylparaben (PrP), butylparaben, 2,4-dihydroxybenzophenone (BP-1), 2-hydroxy-4-methoxybenzophenone (BP-3) and 4-hydroxybenzophenone were detected in > 50% samples. The concentrations of BP-1 and BP-3 (Spearman's r = 0.57, p < 0.01) and those of MeP and PrP (Spearman's r = 0.68, p < 0.01) were found to be correlated. The urinary concentrations of BP-1 and BP-3 in the first trimester were significantly higher than those in the second or third trimester (Mann-Whitney U test, p < 0.05). These findings provide valuable information for improving the prediction of maternal exposure to these emerging pollutants and for assessing their potential health risks to the mother as well as the offspring.
KW - Different trimesters
KW - Environmental pollutants
KW - Human urine samples
KW - Liquid chromatography-mass spectrometry
KW - Pregnant women
UR - http://www.scopus.com/inward/record.url?scp=85022202527&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2017.07.003
DO - 10.1016/j.scitotenv.2017.07.003
M3 - Journal article
C2 - 28709092
AN - SCOPUS:85022202527
SN - 0048-9697
VL - 607-608
SP - 578
EP - 585
JO - Science of the Total Environment
JF - Science of the Total Environment
ER -
