Exposure assessment of bisphenols in Chinese women during pregnancy: A longitudinal study

Jiufeng Li, Chuansha Wu, Hongzhi Zhao, Yanqiu Zhou, Guodong Cao, Zhiyi Yang, Yanjun HONG, Shunqing Xu, Wei Xia*, Zongwei Cai*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

56 Citations (Scopus)


Bisphenol S (BPS) and bisphenol F (BPF) are increasingly used in manufacturing consumer products to replace the use of bisphenol A (BPA), but exposure data are limited, particularly among pregnant women. Here, we measured BPA, BPS, and BPF levels in urine samples, collected from 941 pregnant women over three trimesters. We examined the correlations, coexposure patterns, variability, and predictors of bisphenols using Spearman's correlation coefficient, percentile analysis, intraclass correlation coefficient, and linear mixed models, respectively. We assessed health risks using average concentrations of bisphenols over three trimesters. The three bisphenols were detected in more than 50% of samples, among which BPA was the predominant one. Cashiers, office workers, teachers, and salespersons had elevated urinary BPS concentrations, while healthcare workers had relatively higher BPA concentrations. About 15 participants had potential health risks induced by exposure to bisphenol mixtures. These findings indicate that exposure to multiple bisphenols at low levels is common over three trimesters. Multiple measurements of urinary BPA and BPS concentrations are needed for more accurate evaluation of the exposure levels during pregnancy, while urinary BPF concentrations during pregnancy are moderately reliable. Occupational exposure should be taken into consideration in future demographic studies.

Original languageEnglish
Pages (from-to)7812-7820
Number of pages9
JournalEnvironmental Science and Technology
Issue number13
Early online date10 Jun 2019
Publication statusPublished - 2 Jul 2019

Scopus Subject Areas

  • Chemistry(all)
  • Environmental Chemistry


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