Exploring the potential therapeutic mechanism of Xiao-Yao-San for major depression

Guang Zheng; Rong Li; Huanhuan Shi; Qi Xiao; Wenpeng Xu; Ying Wang; Cheng Lu; Aiping LYU

doi:10.1109/BIBM.2014.6999365

Exploring the potential therapeutic mechanism of Xiao-Yao-San for major depression

Guang Zheng^*
, Rong Li
, Huanhuan Shi
, Qi Xiao
, Wenpeng Xu
, Ying Wang
, Cheng Lu
, Aiping LYU

^*Corresponding author for this work

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

3 Citations (Scopus)

Abstract

Major depression (MD) is a major public health problem which has a substantial impact on individuals and society. Although it is usually treated with antidepressant in primary care, these therapies accompanied with serious side effects. In the clinic of Chinese medicine, Xiao-Yao-San is the first option for MD with little side effects. Although with clear therapeutic effects, its therapeutic mechanism is obscure. In this study, by integrating leading biomedical knowledge databases, though bioinformatics analysis, we explored the potential therapeutic mechanism of Xiao-Yao-San for MD. The therapeutic mechanism analysis covers aspects of Chinese herbal medicine, chemical compound, target protein, OMIM genes, and pathways enriched. As a result, Xiao-Yao-San's 4 target proteins e.g., ADRB2R, B2AR, ADRB2, and MC4R can be matched in MD's OMIM genes which are mainly enriched in pathways of signal transduction. This research demonstrates that Xiao-Yao-San's target proteins may regulate a wide range of different pathways associated with MD.

Original language	English
Title of host publication	Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
Editors	Huiru Jane Zheng, Xiaohua Hu, Daniel Berrar, Yadong Wang, Werner Dubitzky, Jin-Kao Hao, Kwang-Hyun Cho, David Gilbert
Publisher	IEEE
Pages	229-234
Number of pages	6
ISBN (Electronic)	9781479956692
DOIs	https://doi.org/10.1109/BIBM.2014.6999365
Publication status	Published - 29 Dec 2014
Event	2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014 - Belfast, United Kingdom Duration: 2 Nov 2014 → 5 Nov 2014

Publication series

Name	Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014

Conference

Conference	2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
Country/Territory	United Kingdom
City	Belfast
Period	2/11/14 → 5/11/14

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

major depression
molecular mechanism
traditional Chinese medicine
Xiao-Yao-San

Access to Document

10.1109/BIBM.2014.6999365

Cite this

Zheng, G., Li, R., Shi, H., Xiao, Q., Xu, W., Wang, Y., Lu, C., & LYU, A. (2014). Exploring the potential therapeutic mechanism of Xiao-Yao-San for major depression. In H. J. Zheng, X. Hu, D. Berrar, Y. Wang, W. Dubitzky, J.-K. Hao, K.-H. Cho, & D. Gilbert (Eds.), Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014 (pp. 229-234). (Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014). IEEE. https://doi.org/10.1109/BIBM.2014.6999365

Zheng, Guang ; Li, Rong ; Shi, Huanhuan et al. / Exploring the potential therapeutic mechanism of Xiao-Yao-San for major depression. Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014. editor / Huiru Jane Zheng ; Xiaohua Hu ; Daniel Berrar ; Yadong Wang ; Werner Dubitzky ; Jin-Kao Hao ; Kwang-Hyun Cho ; David Gilbert. IEEE, 2014. pp. 229-234 (Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014).

@inproceedings{71d114a68e3b4bf48d2ce2bdb9680f78,

title = "Exploring the potential therapeutic mechanism of Xiao-Yao-San for major depression",

abstract = "Major depression (MD) is a major public health problem which has a substantial impact on individuals and society. Although it is usually treated with antidepressant in primary care, these therapies accompanied with serious side effects. In the clinic of Chinese medicine, Xiao-Yao-San is the first option for MD with little side effects. Although with clear therapeutic effects, its therapeutic mechanism is obscure. In this study, by integrating leading biomedical knowledge databases, though bioinformatics analysis, we explored the potential therapeutic mechanism of Xiao-Yao-San for MD. The therapeutic mechanism analysis covers aspects of Chinese herbal medicine, chemical compound, target protein, OMIM genes, and pathways enriched. As a result, Xiao-Yao-San's 4 target proteins e.g., ADRB2R, B2AR, ADRB2, and MC4R can be matched in MD's OMIM genes which are mainly enriched in pathways of signal transduction. This research demonstrates that Xiao-Yao-San's target proteins may regulate a wide range of different pathways associated with MD.",

keywords = "major depression, molecular mechanism, traditional Chinese medicine, Xiao-Yao-San",

author = "Guang Zheng and Rong Li and Huanhuan Shi and Qi Xiao and Wenpeng Xu and Ying Wang and Cheng Lu and Aiping LYU",

note = "Publisher Copyright: {\textcopyright} 2014 IEEE.; 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014 ; Conference date: 02-11-2014 Through 05-11-2014",

year = "2014",

month = dec,

day = "29",

doi = "10.1109/BIBM.2014.6999365",

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editor = "Zheng, \{Huiru Jane\} and Xiaohua Hu and Daniel Berrar and Yadong Wang and Werner Dubitzky and Jin-Kao Hao and Kwang-Hyun Cho and David Gilbert",

booktitle = "Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014",

address = "United States",

}

Zheng, G, Li, R, Shi, H, Xiao, Q, Xu, W, Wang, Y, Lu, C & LYU, A 2014, Exploring the potential therapeutic mechanism of Xiao-Yao-San for major depression. in HJ Zheng, X Hu, D Berrar, Y Wang, W Dubitzky, J-K Hao, K-H Cho & D Gilbert (eds), Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014. Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014, IEEE, pp. 229-234, 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014, Belfast, United Kingdom, 2/11/14. https://doi.org/10.1109/BIBM.2014.6999365

Exploring the potential therapeutic mechanism of Xiao-Yao-San for major depression. / Zheng, Guang; Li, Rong; Shi, Huanhuan et al.
Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014. ed. / Huiru Jane Zheng; Xiaohua Hu; Daniel Berrar; Yadong Wang; Werner Dubitzky; Jin-Kao Hao; Kwang-Hyun Cho; David Gilbert. IEEE, 2014. p. 229-234 (Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014).

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

TY - GEN

T1 - Exploring the potential therapeutic mechanism of Xiao-Yao-San for major depression

AU - Zheng, Guang

AU - Li, Rong

AU - Shi, Huanhuan

AU - Xiao, Qi

AU - Xu, Wenpeng

AU - Wang, Ying

AU - Lu, Cheng

AU - LYU, Aiping

PY - 2014/12/29

Y1 - 2014/12/29

N2 - Major depression (MD) is a major public health problem which has a substantial impact on individuals and society. Although it is usually treated with antidepressant in primary care, these therapies accompanied with serious side effects. In the clinic of Chinese medicine, Xiao-Yao-San is the first option for MD with little side effects. Although with clear therapeutic effects, its therapeutic mechanism is obscure. In this study, by integrating leading biomedical knowledge databases, though bioinformatics analysis, we explored the potential therapeutic mechanism of Xiao-Yao-San for MD. The therapeutic mechanism analysis covers aspects of Chinese herbal medicine, chemical compound, target protein, OMIM genes, and pathways enriched. As a result, Xiao-Yao-San's 4 target proteins e.g., ADRB2R, B2AR, ADRB2, and MC4R can be matched in MD's OMIM genes which are mainly enriched in pathways of signal transduction. This research demonstrates that Xiao-Yao-San's target proteins may regulate a wide range of different pathways associated with MD.

AB - Major depression (MD) is a major public health problem which has a substantial impact on individuals and society. Although it is usually treated with antidepressant in primary care, these therapies accompanied with serious side effects. In the clinic of Chinese medicine, Xiao-Yao-San is the first option for MD with little side effects. Although with clear therapeutic effects, its therapeutic mechanism is obscure. In this study, by integrating leading biomedical knowledge databases, though bioinformatics analysis, we explored the potential therapeutic mechanism of Xiao-Yao-San for MD. The therapeutic mechanism analysis covers aspects of Chinese herbal medicine, chemical compound, target protein, OMIM genes, and pathways enriched. As a result, Xiao-Yao-San's 4 target proteins e.g., ADRB2R, B2AR, ADRB2, and MC4R can be matched in MD's OMIM genes which are mainly enriched in pathways of signal transduction. This research demonstrates that Xiao-Yao-San's target proteins may regulate a wide range of different pathways associated with MD.

KW - major depression

KW - molecular mechanism

KW - traditional Chinese medicine

KW - Xiao-Yao-San

UR - https://www.scopus.com/pages/publications/84922806804

U2 - 10.1109/BIBM.2014.6999365

DO - 10.1109/BIBM.2014.6999365

M3 - Conference proceeding

AN - SCOPUS:84922806804

T3 - Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014

SP - 229

EP - 234

BT - Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014

A2 - Zheng, Huiru Jane

A2 - Hu, Xiaohua

A2 - Berrar, Daniel

A2 - Wang, Yadong

A2 - Dubitzky, Werner

A2 - Hao, Jin-Kao

A2 - Cho, Kwang-Hyun

A2 - Gilbert, David

PB - IEEE

T2 - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014

Y2 - 2 November 2014 through 5 November 2014

ER -

Zheng G, Li R, Shi H, Xiao Q, Xu W, Wang Y et al. Exploring the potential therapeutic mechanism of Xiao-Yao-San for major depression. In Zheng HJ, Hu X, Berrar D, Wang Y, Dubitzky W, Hao JK, Cho KH, Gilbert D, editors, Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014. IEEE. 2014. p. 229-234. (Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014). doi: 10.1109/BIBM.2014.6999365

Exploring the potential therapeutic mechanism of Xiao-Yao-San for major depression

Abstract

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