TY - GEN
T1 - Exploring the potential therapeutic mechanism of Xiao-Yao-San for major depression
AU - Zheng, Guang
AU - Li, Rong
AU - Shi, Huanhuan
AU - Xiao, Qi
AU - Xu, Wenpeng
AU - Wang, Ying
AU - Lu, Cheng
AU - LYU, Aiping
N1 - Publisher Copyright:
© 2014 IEEE.
PY - 2014/12/29
Y1 - 2014/12/29
N2 - Major depression (MD) is a major public health problem which has a substantial impact on individuals and society. Although it is usually treated with antidepressant in primary care, these therapies accompanied with serious side effects. In the clinic of Chinese medicine, Xiao-Yao-San is the first option for MD with little side effects. Although with clear therapeutic effects, its therapeutic mechanism is obscure. In this study, by integrating leading biomedical knowledge databases, though bioinformatics analysis, we explored the potential therapeutic mechanism of Xiao-Yao-San for MD. The therapeutic mechanism analysis covers aspects of Chinese herbal medicine, chemical compound, target protein, OMIM genes, and pathways enriched. As a result, Xiao-Yao-San's 4 target proteins e.g., ADRB2R, B2AR, ADRB2, and MC4R can be matched in MD's OMIM genes which are mainly enriched in pathways of signal transduction. This research demonstrates that Xiao-Yao-San's target proteins may regulate a wide range of different pathways associated with MD.
AB - Major depression (MD) is a major public health problem which has a substantial impact on individuals and society. Although it is usually treated with antidepressant in primary care, these therapies accompanied with serious side effects. In the clinic of Chinese medicine, Xiao-Yao-San is the first option for MD with little side effects. Although with clear therapeutic effects, its therapeutic mechanism is obscure. In this study, by integrating leading biomedical knowledge databases, though bioinformatics analysis, we explored the potential therapeutic mechanism of Xiao-Yao-San for MD. The therapeutic mechanism analysis covers aspects of Chinese herbal medicine, chemical compound, target protein, OMIM genes, and pathways enriched. As a result, Xiao-Yao-San's 4 target proteins e.g., ADRB2R, B2AR, ADRB2, and MC4R can be matched in MD's OMIM genes which are mainly enriched in pathways of signal transduction. This research demonstrates that Xiao-Yao-San's target proteins may regulate a wide range of different pathways associated with MD.
KW - major depression
KW - molecular mechanism
KW - traditional Chinese medicine
KW - Xiao-Yao-San
UR - http://www.scopus.com/inward/record.url?scp=84922806804&partnerID=8YFLogxK
U2 - 10.1109/BIBM.2014.6999365
DO - 10.1109/BIBM.2014.6999365
M3 - Conference proceeding
AN - SCOPUS:84922806804
T3 - Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
SP - 229
EP - 234
BT - Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
A2 - Zheng, Huiru
A2 - Hu, Xiaohua Tony
A2 - Berrar, Daniel
A2 - Wang, Yadong
A2 - Dubitzky, Werner
A2 - Hao, Jin-Kao
A2 - Cho, Kwang-Hyun
A2 - Gilbert, David
PB - IEEE
T2 - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
Y2 - 2 November 2014 through 5 November 2014
ER -
