TY - GEN
T1 - Exploring the potential therapeutic mechanism of Da-Fang-Feng-Tang for rheumatoid arthritis
AU - Zheng, Guang
AU - Shi, Huanhuan
AU - Yi, Xiaolie
AU - Wang, Lingru
AU - Song, Mengmeng
AU - He, Xiaojuan
AU - LYU, Aiping
N1 - Publisher Copyright:
© 2014 IEEE.
PY - 2014/12/29
Y1 - 2014/12/29
N2 - Da-Fang-Feng-Tang is a Chinese herbal formula designed to treat syndrome Feng-Han-Shi-Bi for rheumatoid arthritis (RA). Although it's clinical effect have been accepted through 1000 years' clinical practises, its molecule mechanism is still obscure. In this study, by integrating powerful knowledge databases, though bioinformatics analysis, we explored the potential molecular mechanism of Da-Fang-Feng-Tang for RA. The molecule mechanism analysis includes compositional herbal medicine, chemical compound, target protein, RA OMIM genes, and enriched pathways. As a result, Da-Feng-Feng-Tang's 7 target proteins were matched in RA's OMIM genes. What's more, these 7 genes are mainly involved in three pathway hierarchies e.g., disease, immune system, and signal transduction. This research demonstrates that Da-Feng-Feng-Tang's target proteins can regulate a wide range of systems associated with RA. This might indicate that Chinese herbal formula's therapeutic effects are taken effects through system-level regulation rather than targeting only disease specified genes or proteins.
AB - Da-Fang-Feng-Tang is a Chinese herbal formula designed to treat syndrome Feng-Han-Shi-Bi for rheumatoid arthritis (RA). Although it's clinical effect have been accepted through 1000 years' clinical practises, its molecule mechanism is still obscure. In this study, by integrating powerful knowledge databases, though bioinformatics analysis, we explored the potential molecular mechanism of Da-Fang-Feng-Tang for RA. The molecule mechanism analysis includes compositional herbal medicine, chemical compound, target protein, RA OMIM genes, and enriched pathways. As a result, Da-Feng-Feng-Tang's 7 target proteins were matched in RA's OMIM genes. What's more, these 7 genes are mainly involved in three pathway hierarchies e.g., disease, immune system, and signal transduction. This research demonstrates that Da-Feng-Feng-Tang's target proteins can regulate a wide range of systems associated with RA. This might indicate that Chinese herbal formula's therapeutic effects are taken effects through system-level regulation rather than targeting only disease specified genes or proteins.
KW - Da-Fang-Feng-Tang
KW - molecular mechanism
KW - rheumatoid arthritis
KW - traditional Chinese medicine
UR - http://www.scopus.com/inward/record.url?scp=84922761861&partnerID=8YFLogxK
U2 - 10.1109/BIBM.2014.6999280
DO - 10.1109/BIBM.2014.6999280
M3 - Conference proceeding
AN - SCOPUS:84922761861
T3 - Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
SP - 40
EP - 45
BT - Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
A2 - Zheng, Huiru (Jane)
A2 - Hu, Xiaohua
A2 - Berrar, Daniel
A2 - Wang, Yadong
A2 - Dubitzky, Werner
A2 - Hao, Jin-Kao
A2 - Cho, Kwang-Hyun
A2 - Gilbert, David
PB - IEEE
T2 - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
Y2 - 2 November 2014 through 5 November 2014
ER -