Exploring the potential therapeutic mechanism of Da-Fang-Feng-Tang for rheumatoid arthritis

Guang Zheng*, Huanhuan Shi, Xiaolie Yi, Lingru Wang, Mengmeng Song, Xiaojuan He, Aiping LYU

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingConference contributionpeer-review

Abstract

Da-Fang-Feng-Tang is a Chinese herbal formula designed to treat syndrome Feng-Han-Shi-Bi for rheumatoid arthritis (RA). Although it's clinical effect have been accepted through 1000 years' clinical practises, its molecule mechanism is still obscure. In this study, by integrating powerful knowledge databases, though bioinformatics analysis, we explored the potential molecular mechanism of Da-Fang-Feng-Tang for RA. The molecule mechanism analysis includes compositional herbal medicine, chemical compound, target protein, RA OMIM genes, and enriched pathways. As a result, Da-Feng-Feng-Tang's 7 target proteins were matched in RA's OMIM genes. What's more, these 7 genes are mainly involved in three pathway hierarchies e.g., disease, immune system, and signal transduction. This research demonstrates that Da-Feng-Feng-Tang's target proteins can regulate a wide range of systems associated with RA. This might indicate that Chinese herbal formula's therapeutic effects are taken effects through system-level regulation rather than targeting only disease specified genes or proteins.

Original languageEnglish
Title of host publicationProceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
EditorsHuiru Zheng, Xiaohua Tony Hu, Yadong Wang, Jin-Kao Hao, David Gilbert, Daniel Berrar, Kwang-Hyun Cho, Werner Dubitzky
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages40-45
Number of pages6
ISBN (Electronic)9781479956692
DOIs
Publication statusPublished - 29 Dec 2014
Event2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014 - Belfast, United Kingdom
Duration: 2 Nov 20145 Nov 2014

Publication series

NameProceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014

Conference

Conference2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
Country/TerritoryUnited Kingdom
CityBelfast
Period2/11/145/11/14

Scopus Subject Areas

  • Biomedical Engineering
  • Health Informatics

User-Defined Keywords

  • Da-Fang-Feng-Tang
  • molecular mechanism
  • rheumatoid arthritis
  • traditional Chinese medicine

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