TY - GEN
T1 - Exploring the molecular mechanism of Juan-Bi-Tang for Feng-Han-Shi-Bi syndrome in rheumatoid arthritis
AU - Zheng, Guang
AU - Song, Mengmeng
AU - He, Biao
AU - Li, Xiaoqing
AU - Luo, Jia
AU - LYU, Aiping
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks flexible (synovial) joints. Traditional Chinese medicine (TCM) treats RA with herbal formulae according to different syndrome/pattern classification. One important syndrome/pattern in RA is Feng-Han-Shi-Bi. Targeting this syndrome, Juan-Bi-Tang is the basic herbal formula adopted in clinical practises with reliable therapeutic effect. However, the mechanism of Juan-Bi-Tang is still not clear. In this study, we explored the molecular mechanism of Juan-Bi-Tang with in silico analysis on its 11 herbal medicines' chemical compounds, target proteins, protein-protein interaction, and pathway. As a result, the molecular mechanism of Juan-Bi-Tang for Feng-Han-Shi-Bi syndrome in RA covers a variety of biological processes including immune system, signal transduction, metabolism, disease etc. Most of them are relevant to RA which indicate actual therapeutic effect of TCM clinical practises.
AB - Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks flexible (synovial) joints. Traditional Chinese medicine (TCM) treats RA with herbal formulae according to different syndrome/pattern classification. One important syndrome/pattern in RA is Feng-Han-Shi-Bi. Targeting this syndrome, Juan-Bi-Tang is the basic herbal formula adopted in clinical practises with reliable therapeutic effect. However, the mechanism of Juan-Bi-Tang is still not clear. In this study, we explored the molecular mechanism of Juan-Bi-Tang with in silico analysis on its 11 herbal medicines' chemical compounds, target proteins, protein-protein interaction, and pathway. As a result, the molecular mechanism of Juan-Bi-Tang for Feng-Han-Shi-Bi syndrome in RA covers a variety of biological processes including immune system, signal transduction, metabolism, disease etc. Most of them are relevant to RA which indicate actual therapeutic effect of TCM clinical practises.
KW - Feng-Han-Shi-Bi syndrome
KW - Molecular mechanism
KW - Rheumatoid arthritis
KW - Traditional Chinese medicine
UR - http://www.scopus.com/inward/record.url?scp=84894543993&partnerID=8YFLogxK
U2 - 10.1109/BIBM.2013.6732769
DO - 10.1109/BIBM.2013.6732769
M3 - Conference proceeding
AN - SCOPUS:84894543993
SN - 9781479913091
T3 - Proceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013
SP - 77
EP - 79
BT - Proceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013
T2 - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013
Y2 - 18 December 2013 through 21 December 2013
ER -