Exploring the molecular mechanism of Juan-Bi-Tang for Feng-Han-Shi-Bi syndrome in rheumatoid arthritis

Guang Zheng*, Mengmeng Song, Biao He, Xiaoqing Li, Jia Luo, Aiping LYU

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingConference proceedingpeer-review

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks flexible (synovial) joints. Traditional Chinese medicine (TCM) treats RA with herbal formulae according to different syndrome/pattern classification. One important syndrome/pattern in RA is Feng-Han-Shi-Bi. Targeting this syndrome, Juan-Bi-Tang is the basic herbal formula adopted in clinical practises with reliable therapeutic effect. However, the mechanism of Juan-Bi-Tang is still not clear. In this study, we explored the molecular mechanism of Juan-Bi-Tang with in silico analysis on its 11 herbal medicines' chemical compounds, target proteins, protein-protein interaction, and pathway. As a result, the molecular mechanism of Juan-Bi-Tang for Feng-Han-Shi-Bi syndrome in RA covers a variety of biological processes including immune system, signal transduction, metabolism, disease etc. Most of them are relevant to RA which indicate actual therapeutic effect of TCM clinical practises.

Original languageEnglish
Title of host publicationProceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013
Pages77-79
Number of pages3
DOIs
Publication statusPublished - 2013
Event2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013 - Shanghai, China
Duration: 18 Dec 201321 Dec 2013

Publication series

NameProceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013

Conference

Conference2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013
Country/TerritoryChina
CityShanghai
Period18/12/1321/12/13

Scopus Subject Areas

  • Biomedical Engineering

User-Defined Keywords

  • Feng-Han-Shi-Bi syndrome
  • Molecular mechanism
  • Rheumatoid arthritis
  • Traditional Chinese medicine

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