TY - GEN
T1 - Exploring potential therapeutic agents of Duhuo-Jisheng-Tang for rheumatoid arthritis
AU - Zheng, Guang
AU - Wei, Tong
AU - Ma, Changsheng
AU - Liu, Jianjun
AU - Liu, Jinyu
AU - Lu, Cheng
AU - LYU, Aiping
N1 - Publisher Copyright:
© 2014 IEEE.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2014/12/29
Y1 - 2014/12/29
N2 - Duhuo-Jisheng-Tang is a Chinese herbal formula designed to treat rheumatoid arthritis (RA) with syndrome dual deficiency of liver and kidney. Although its therapeutic clinical effect is widely accepted over one thousand years, its therapeutic agents are still obscure. In this study, we explored the potential therapeutic agents of Duhuo-Jisheng-Tang for RA by integrating leading knowledge databases of different biomedical domains. The molecule mechanism includes compositional herbal medicine, chemical compound, target protein, RA OMIM genes, FDA approved RA drug targets, and pathways. As a result, Duhuo-Jisheng-Tang's 11 target proteins can be found in RA's OMIM genes (e.g., UGT1, UGT1A9, GNT1, and JAK3) and FDA approved RA drug targets (e.g., CMKBR2/5, CCR2/5, APRF, and STAT1/3). What's more, these 11 genes/proteins are mainly enriched in pathways of disease, immune system, signal transduction, and metabolism. It demonstrates that Duhuo-Jisheng-Tang may regulate a wide range of different systems associated with RA which might indicate that Chinese herbal formula's therapeutic effects are demonstrated through system-level regulation rather than targeting disease specified genes/proteins.
AB - Duhuo-Jisheng-Tang is a Chinese herbal formula designed to treat rheumatoid arthritis (RA) with syndrome dual deficiency of liver and kidney. Although its therapeutic clinical effect is widely accepted over one thousand years, its therapeutic agents are still obscure. In this study, we explored the potential therapeutic agents of Duhuo-Jisheng-Tang for RA by integrating leading knowledge databases of different biomedical domains. The molecule mechanism includes compositional herbal medicine, chemical compound, target protein, RA OMIM genes, FDA approved RA drug targets, and pathways. As a result, Duhuo-Jisheng-Tang's 11 target proteins can be found in RA's OMIM genes (e.g., UGT1, UGT1A9, GNT1, and JAK3) and FDA approved RA drug targets (e.g., CMKBR2/5, CCR2/5, APRF, and STAT1/3). What's more, these 11 genes/proteins are mainly enriched in pathways of disease, immune system, signal transduction, and metabolism. It demonstrates that Duhuo-Jisheng-Tang may regulate a wide range of different systems associated with RA which might indicate that Chinese herbal formula's therapeutic effects are demonstrated through system-level regulation rather than targeting disease specified genes/proteins.
KW - Duhuo-Jisheng-Tang
KW - molecular mechanism
KW - rheumatoid arthritis
KW - traditional Chinese medicine
UR - http://www.scopus.com/inward/record.url?scp=84922798041&partnerID=8YFLogxK
U2 - 10.1109/BIBM.2014.6999203
DO - 10.1109/BIBM.2014.6999203
M3 - Conference contribution
AN - SCOPUS:84922798041
T3 - Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
SP - 476
EP - 479
BT - Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
A2 - Zheng, Huiru
A2 - Hu, Xiaohua Tony
A2 - Wang, Yadong
A2 - Hao, Jin-Kao
A2 - Gilbert, David
A2 - Berrar, Daniel
A2 - Cho, Kwang-Hyun
A2 - Dubitzky, Werner
PB - IEEE
T2 - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014
Y2 - 2 November 2014 through 5 November 2014
ER -