TY - JOUR
T1 - Exploring fructose metabolism as a potential therapeutic approach for pancreatic cancer
AU - Wang, Chengqiang
AU - Wang, Lu
AU - Zhao, Qing
AU - Ma, Jiao
AU - Li, Yitao
AU - Kuang, Junliang
AU - Yang, Xintong
AU - Lu, Aiping
AU - Cheung, Kenneth Chat Pan
AU - Melino, Gerry
AU - Jia, Wei
N1 - This work was supported by Guangdong-Hong Kong-Macao Joint Laboratory for New Drug Screening (2023B1212120005).
Publisher Copyright:
© 2024 Springer Nature Limited
under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare 2024
PY - 2024/12
Y1 - 2024/12
N2 - Excessive fructose intake has been associated with the development and progression of pancreatic cancer. This study aimed to elucidate the relationship between fructose utilization and pancreatic cancer progression. Our findings revealed that pancreatic cancer cells have a high capacity to utilize fructose and are capable of converting glucose to fructose via the AKR1B1-mediated polyol pathway, in addition to uptake via the fructose transporter GLUT5. Fructose metabolism exacerbates pancreatic cancer proliferation by enhancing glycolysis and accelerating the production of key metabolites that regulate angiogenesis. However, pharmacological blockade of fructose metabolism has been shown to slow pancreatic cancer progression and synergistically enhance anti-tumor capabilities when combined with anti-angiogenic agents. Overall, targeting fructose metabolism may prove to be a promising therapeutic approach in the treatment of pancreatic cancer.
AB - Excessive fructose intake has been associated with the development and progression of pancreatic cancer. This study aimed to elucidate the relationship between fructose utilization and pancreatic cancer progression. Our findings revealed that pancreatic cancer cells have a high capacity to utilize fructose and are capable of converting glucose to fructose via the AKR1B1-mediated polyol pathway, in addition to uptake via the fructose transporter GLUT5. Fructose metabolism exacerbates pancreatic cancer proliferation by enhancing glycolysis and accelerating the production of key metabolites that regulate angiogenesis. However, pharmacological blockade of fructose metabolism has been shown to slow pancreatic cancer progression and synergistically enhance anti-tumor capabilities when combined with anti-angiogenic agents. Overall, targeting fructose metabolism may prove to be a promising therapeutic approach in the treatment of pancreatic cancer.
UR - https://www.nature.com/articles/s41418-024-01394-3
UR - http://www.scopus.com/inward/record.url?scp=85206844065&partnerID=8YFLogxK
U2 - 10.1038/s41418-024-01394-3
DO - 10.1038/s41418-024-01394-3
M3 - Journal article
SN - 1350-9047
VL - 31
SP - 1625
EP - 1635
JO - Cell Death and Differentiation
JF - Cell Death and Differentiation
IS - 12
ER -
