TY - JOUR
T1 - Exploring different strategies for efficient delivery of colorectal cancer therapy
AU - Lin, Congcong
AU - Ng, Huei Leng Helena
AU - Pan, Weisan
AU - CHEN, Hubiao
AU - ZHANG, Ge
AU - BIAN, Zhaoxiang
AU - LYU, Aiping
AU - YANG, Zhijun
N1 - Publisher Copyright:
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
PY - 2015/11/11
Y1 - 2015/11/11
N2 - Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer death in the world. Currently available chemotherapy of CRC usually delivers the drug to both normal as well as cancerous tissues, thus leading to numerous undesirable effects. Much emphasis is being laid on the development of effective drug delivery systems for achieving selective delivery of the active moiety at the anticipated site of action with minimized unwanted side effects. Researchers have employed various techniques (dependent on pH, time, pressure and/or bacteria) for targeting drugs directly to the colonic region. On the other hand, systemic drug delivery strategies to specific molecular targets (such as FGFR, EGFR, CD44, EpCAM, CA IX, PPAR and COX-2) overexpressed by cancerous cells have also been shown to be effective. This review aims to put forth an overview of drug delivery technologies that have been, and may be developed, for the treatment of CRC.
AB - Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer death in the world. Currently available chemotherapy of CRC usually delivers the drug to both normal as well as cancerous tissues, thus leading to numerous undesirable effects. Much emphasis is being laid on the development of effective drug delivery systems for achieving selective delivery of the active moiety at the anticipated site of action with minimized unwanted side effects. Researchers have employed various techniques (dependent on pH, time, pressure and/or bacteria) for targeting drugs directly to the colonic region. On the other hand, systemic drug delivery strategies to specific molecular targets (such as FGFR, EGFR, CD44, EpCAM, CA IX, PPAR and COX-2) overexpressed by cancerous cells have also been shown to be effective. This review aims to put forth an overview of drug delivery technologies that have been, and may be developed, for the treatment of CRC.
KW - Chemotherapy
KW - Colon-specific drug delivery system
KW - Colorectal cancer
KW - Drug delivery system
KW - Systemic drug delivery system
UR - http://www.scopus.com/inward/record.url?scp=84946962418&partnerID=8YFLogxK
U2 - 10.3390/ijms161125995
DO - 10.3390/ijms161125995
M3 - Review article
C2 - 26569228
AN - SCOPUS:84946962418
SN - 1661-6596
VL - 16
SP - 26936
EP - 26952
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 11
ER -
