Exploration of lung mycobiome in the patients with non-small-cell lung cancer

Yiming Zhao, Junqi Yi, Juanjuan Xiang, Wei Jia, Anqi Chen, Liyu Chen, Leliang Zheng, Wen Zhou, Minghua Wu, Zheng Yu*, Jingqun Tang*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

6 Citations (Scopus)

Abstract

As the Human Microbiome Project (HMP) progresses, the relationship between microbes and human health has been receiving increasing attention. A growing number of reports support the correlation between cancer and microbes. However, most studies have focused on bacteria, rather than fungal communities. In this study, we studied the alteration in lung mycobiome in patients with non-small-cell lung cancer (NSCLC) using metagenomic sequencing and qPCR. The higher fungal diversity and more complex network were observed in the patients with NSCLC. In addition, Alternaria arborescens was found as the most relevant fungus to NSCLC, and the enrichment of it in cancerous tissue was also detected. This study proposes that the changes in fungal communities may be closely related to lung cancer, and provides insights into further exploration the relationship between lung cancer and fungi.

Original languageEnglish
Article number81
Number of pages12
JournalBMC Microbiology
Volume23
DOIs
Publication statusPublished - 25 Mar 2023

Scopus Subject Areas

  • Microbiology
  • Microbiology (medical)

User-Defined Keywords

  • Alternaria arborescens
  • Mycobiome
  • Non-small-cell lung cancer

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