Exosomes-mediated tumor metastasis through reshaping tumor microenvironment and distant niche

Xinyi Luo; Yang Li; Zhenglai Hua; Xiaoxia Xue; Xiangpeng Wang; Mingshi Pang; Cheng Xiao; Hongyan Zhao; Aiping Lyu; Yuanyan Liu

doi:10.1016/j.jconrel.2022.11.050

Exosomes-mediated tumor metastasis through reshaping tumor microenvironment and distant niche

Xinyi Luo, Yang Li, Zhenglai Hua, Xiaoxia Xue, Xiangpeng Wang, Mingshi Pang, Cheng Xiao^*, Hongyan Zhao^*, Aiping Lyu^*, Yuanyan Liu^*

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Review article › peer-review

31 Citations (Scopus)

Abstract

Tumor-derived exosomes (TDEs) are the particular communicator and messenger between tumor cells and other cells containing cancer-associated genetic materials and proteins. And TDEs who are also one of the important components consisting of the tumor microenvironment (TME) can reshape and interact with TME to promote tumor development and metastasis. Moreover, due to their long-distance transmission by body fluids, TDEs can facilitate the formation of pre-metastatic niche to support tumor colonization. We discuss the main characteristics and mechanism of TDE-mediated tumor metastasis by reshaping TME and pre-metastatic niche as well as the potential of TDEs for diagnosing tumor and predicting future metastatic development.

Original language	English
Pages (from-to)	327-336
Number of pages	10
Journal	Journal of Controlled Release
Volume	353
DOIs	https://doi.org/10.1016/j.jconrel.2022.11.050
Publication status	Published - Jan 2023

Scopus Subject Areas

Pharmaceutical Science

User-Defined Keywords

Metastasis
Pre-metastatic niche
Prediction
Tumor microenvironment
Tumor-derived exosomes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jconrel.2022.11.050

Cite this

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title = "Exosomes-mediated tumor metastasis through reshaping tumor microenvironment and distant niche",

abstract = "Tumor-derived exosomes (TDEs) are the particular communicator and messenger between tumor cells and other cells containing cancer-associated genetic materials and proteins. And TDEs who are also one of the important components consisting of the tumor microenvironment (TME) can reshape and interact with TME to promote tumor development and metastasis. Moreover, due to their long-distance transmission by body fluids, TDEs can facilitate the formation of pre-metastatic niche to support tumor colonization. We discuss the main characteristics and mechanism of TDE-mediated tumor metastasis by reshaping TME and pre-metastatic niche as well as the potential of TDEs for diagnosing tumor and predicting future metastatic development.",

keywords = "Metastasis, Pre-metastatic niche, Prediction, Tumor microenvironment, Tumor-derived exosomes",

author = "Xinyi Luo and Yang Li and Zhenglai Hua and Xiaoxia Xue and Xiangpeng Wang and Mingshi Pang and Cheng Xiao and Hongyan Zhao and Aiping Lyu and Yuanyan Liu",

note = "A special thanks for the long-term subsidy mechanism from the Ministry of Finance and the Ministry of Education of PRC (People's Republic of China) for BUCM (Beijing University of Chinese Medicine). This study was financially supported by the National Natural Science Foundation of China (Grant number: U22A20374). Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2023",

month = jan,

doi = "10.1016/j.jconrel.2022.11.050",

language = "English",

volume = "353",

pages = "327--336",

journal = "Journal of Controlled Release",

issn = "0168-3659",

publisher = "Elsevier",

}

TY - JOUR

T1 - Exosomes-mediated tumor metastasis through reshaping tumor microenvironment and distant niche

AU - Luo, Xinyi

AU - Li, Yang

AU - Hua, Zhenglai

AU - Xue, Xiaoxia

AU - Wang, Xiangpeng

AU - Pang, Mingshi

AU - Xiao, Cheng

AU - Zhao, Hongyan

AU - Lyu, Aiping

AU - Liu, Yuanyan

N1 - A special thanks for the long-term subsidy mechanism from the Ministry of Finance and the Ministry of Education of PRC (People's Republic of China) for BUCM (Beijing University of Chinese Medicine). This study was financially supported by the National Natural Science Foundation of China (Grant number: U22A20374). Publisher Copyright: © 2022 Elsevier B.V.

PY - 2023/1

Y1 - 2023/1

N2 - Tumor-derived exosomes (TDEs) are the particular communicator and messenger between tumor cells and other cells containing cancer-associated genetic materials and proteins. And TDEs who are also one of the important components consisting of the tumor microenvironment (TME) can reshape and interact with TME to promote tumor development and metastasis. Moreover, due to their long-distance transmission by body fluids, TDEs can facilitate the formation of pre-metastatic niche to support tumor colonization. We discuss the main characteristics and mechanism of TDE-mediated tumor metastasis by reshaping TME and pre-metastatic niche as well as the potential of TDEs for diagnosing tumor and predicting future metastatic development.

AB - Tumor-derived exosomes (TDEs) are the particular communicator and messenger between tumor cells and other cells containing cancer-associated genetic materials and proteins. And TDEs who are also one of the important components consisting of the tumor microenvironment (TME) can reshape and interact with TME to promote tumor development and metastasis. Moreover, due to their long-distance transmission by body fluids, TDEs can facilitate the formation of pre-metastatic niche to support tumor colonization. We discuss the main characteristics and mechanism of TDE-mediated tumor metastasis by reshaping TME and pre-metastatic niche as well as the potential of TDEs for diagnosing tumor and predicting future metastatic development.

KW - Metastasis

KW - Pre-metastatic niche

KW - Prediction

KW - Tumor microenvironment

KW - Tumor-derived exosomes

UR - http://www.scopus.com/inward/record.url?scp=85146220368&partnerID=8YFLogxK

U2 - 10.1016/j.jconrel.2022.11.050

DO - 10.1016/j.jconrel.2022.11.050

M3 - Review article

C2 - 36464063

AN - SCOPUS:85146220368

SN - 0168-3659

VL - 353

SP - 327

EP - 336

JO - Journal of Controlled Release

JF - Journal of Controlled Release

ER -

Exosomes-mediated tumor metastasis through reshaping tumor microenvironment and distant niche

Abstract

Scopus Subject Areas

User-Defined Keywords

UN SDGs

Access to Document

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