Excitation energy transfer in ruthenium (II)-porphyrin conjugates led to enhanced emission quantum yield and 1O2 generation

Jie Pan; Lijun Jiang; Chi Fai Chan; Tik Hung Tsoi; Kwok Keung SHIU; Daniel W J KWONG; Wing Tak Wong; Rick W K WONG; Ka-Leung WONG

doi:10.1016/j.jlumin.2016.12.024

Excitation energy transfer in ruthenium (II)-porphyrin conjugates led to enhanced emission quantum yield and ¹O₂ generation

Jie Pan
, Lijun Jiang
, Chi Fai Chan
, Tik Hung Tsoi
, Kwok Keung SHIU^*
, Daniel W J KWONG
, Wing Tak Wong
, Rick W K WONG
, Ka-Leung WONG

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

18 Citations (Scopus)

Abstract

Porphyrins are good photodynamic therapy (PDT) agents due to its flexibility for modifications to achieve tumor localization and photo-cytotoxicity against cancer. Yet they are not perfect. In a Ru(polypyridyl)-porphyrin system, the Ru(polypyridyl) moiety improves the water solubility and cell permeability. Consider the similar excited state energies between Ru(polypyridyl) and porphyrin moieties; a small perturbation (e.g. Zn(II) metalation) would lead to a marked change in the energy migration process. In this work, we have synthesized a series of porphyrins conjugated with Ru(polypyridyl) complexes using different linkers and investigated their photophysical properties, which included singlet oxygen quantum yield and their in vitro biological properties, resulting from linker variation and porphyrin modification by Zn(II) metalation.

Original language	English
Pages (from-to)	89-95
Number of pages	7
Journal	Journal of Luminescence
Volume	184
DOIs	https://doi.org/10.1016/j.jlumin.2016.12.024
Publication status	Published - 1 Apr 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

Fluorescence probe
Luminescent material
Photodynamic therapy
Porphyrin
Ruthenium

Access to Document

10.1016/j.jlumin.2016.12.024

Cite this

@article{44e7335e9516421d85802dcfef1df7fa,

title = "Excitation energy transfer in ruthenium (II)-porphyrin conjugates led to enhanced emission quantum yield and 1O2 generation",

abstract = "Porphyrins are good photodynamic therapy (PDT) agents due to its flexibility for modifications to achieve tumor localization and photo-cytotoxicity against cancer. Yet they are not perfect. In a Ru(polypyridyl)-porphyrin system, the Ru(polypyridyl) moiety improves the water solubility and cell permeability. Consider the similar excited state energies between Ru(polypyridyl) and porphyrin moieties; a small perturbation (e.g. Zn(II) metalation) would lead to a marked change in the energy migration process. In this work, we have synthesized a series of porphyrins conjugated with Ru(polypyridyl) complexes using different linkers and investigated their photophysical properties, which included singlet oxygen quantum yield and their in vitro biological properties, resulting from linker variation and porphyrin modification by Zn(II) metalation.",

keywords = "Fluorescence probe, Luminescent material, Photodynamic therapy, Porphyrin, Ruthenium",

author = "Jie Pan and Lijun Jiang and Chan, \{Chi Fai\} and Tsoi, \{Tik Hung\} and SHIU, \{Kwok Keung\} and KWONG, \{Daniel W J\} and Wong, \{Wing Tak\} and WONG, \{Rick W K\} and Ka-Leung WONG",

note = "This work was funded by grants from The Hong Kong Research Grants Council (HKBU 203112), EPSRC, HKBU-HK PolyU Joint Research Programme (RC-ICRS/15-16/02F-WKL02F-WKL and RC-ICRS/15-16/02D-KWJ) and Prospective Joint Research Project (BY2015042-01).",

year = "2017",

month = apr,

day = "1",

doi = "10.1016/j.jlumin.2016.12.024",

language = "English",

volume = "184",

pages = "89--95",

journal = "Journal of Luminescence",

issn = "0022-2313",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Excitation energy transfer in ruthenium (II)-porphyrin conjugates led to enhanced emission quantum yield and 1O2 generation

AU - Pan, Jie

AU - Jiang, Lijun

AU - Chan, Chi Fai

AU - Tsoi, Tik Hung

AU - SHIU, Kwok Keung

AU - KWONG, Daniel W J

AU - Wong, Wing Tak

AU - WONG, Rick W K

AU - WONG, Ka-Leung

N1 - This work was funded by grants from The Hong Kong Research Grants Council (HKBU 203112), EPSRC, HKBU-HK PolyU Joint Research Programme (RC-ICRS/15-16/02F-WKL02F-WKL and RC-ICRS/15-16/02D-KWJ) and Prospective Joint Research Project (BY2015042-01).

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Porphyrins are good photodynamic therapy (PDT) agents due to its flexibility for modifications to achieve tumor localization and photo-cytotoxicity against cancer. Yet they are not perfect. In a Ru(polypyridyl)-porphyrin system, the Ru(polypyridyl) moiety improves the water solubility and cell permeability. Consider the similar excited state energies between Ru(polypyridyl) and porphyrin moieties; a small perturbation (e.g. Zn(II) metalation) would lead to a marked change in the energy migration process. In this work, we have synthesized a series of porphyrins conjugated with Ru(polypyridyl) complexes using different linkers and investigated their photophysical properties, which included singlet oxygen quantum yield and their in vitro biological properties, resulting from linker variation and porphyrin modification by Zn(II) metalation.

AB - Porphyrins are good photodynamic therapy (PDT) agents due to its flexibility for modifications to achieve tumor localization and photo-cytotoxicity against cancer. Yet they are not perfect. In a Ru(polypyridyl)-porphyrin system, the Ru(polypyridyl) moiety improves the water solubility and cell permeability. Consider the similar excited state energies between Ru(polypyridyl) and porphyrin moieties; a small perturbation (e.g. Zn(II) metalation) would lead to a marked change in the energy migration process. In this work, we have synthesized a series of porphyrins conjugated with Ru(polypyridyl) complexes using different linkers and investigated their photophysical properties, which included singlet oxygen quantum yield and their in vitro biological properties, resulting from linker variation and porphyrin modification by Zn(II) metalation.

KW - Fluorescence probe

KW - Luminescent material

KW - Photodynamic therapy

KW - Porphyrin

KW - Ruthenium

UR - https://www.scopus.com/pages/publications/85007152035

U2 - 10.1016/j.jlumin.2016.12.024

DO - 10.1016/j.jlumin.2016.12.024

M3 - Journal article

AN - SCOPUS:85007152035

SN - 0022-2313

VL - 184

SP - 89

EP - 95

JO - Journal of Luminescence

JF - Journal of Luminescence

ER -