Excitation energy transfer in ruthenium (II)-porphyrin conjugates led to enhanced emission quantum yield and 1O2 generation

Jie Pan, Lijun Jiang, Chi Fai Chan, Tik Hung Tsoi, Kwok Keung SHIU*, Daniel W J KWONG, Wing Tak Wong, Rick W K WONG, Ka-Leung WONG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Porphyrins are good photodynamic therapy (PDT) agents due to its flexibility for modifications to achieve tumor localization and photo-cytotoxicity against cancer. Yet they are not perfect. In a Ru(polypyridyl)-porphyrin system, the Ru(polypyridyl) moiety improves the water solubility and cell permeability. Consider the similar excited state energies between Ru(polypyridyl) and porphyrin moieties; a small perturbation (e.g. Zn(II) metalation) would lead to a marked change in the energy migration process. In this work, we have synthesized a series of porphyrins conjugated with Ru(polypyridyl) complexes using different linkers and investigated their photophysical properties, which included singlet oxygen quantum yield and their in vitro biological properties, resulting from linker variation and porphyrin modification by Zn(II) metalation.

Original languageEnglish
Pages (from-to)89-95
Number of pages7
JournalJournal of Luminescence
Volume184
DOIs
Publication statusPublished - 1 Apr 2017

Scopus Subject Areas

  • Biophysics
  • Atomic and Molecular Physics, and Optics
  • Chemistry(all)
  • Biochemistry
  • Condensed Matter Physics

User-Defined Keywords

  • Fluorescence probe
  • Luminescent material
  • Photodynamic therapy
  • Porphyrin
  • Ruthenium

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