Evaluation of vagal nerve blockade with epineural lignocaine application

Wai Yeung Chung; Shi Ping Zhang

doi:10.23675/sjlas.v30i2.41

Evaluation of vagal nerve blockade with epineural lignocaine application

Wai Yeung Chung, Shi Ping Zhang^*

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Journal article › peer-review

Abstract

The effect of vagal nerve blockade by epineural application of lignocaine was studied in the rat. Vagal nerve conduction was assessed by subdiaphragmatic esophageal electromyogram (EMG) response evoked by stimulation of the cervical vagus nerve. It was found that epineural application of lignocaine completely blocked the evoked EMG response within one minute. After washing away the anesthetic, recovery of nerve conduction was gradual, taking approximately 60 min. Our results have implications for the use of local anesthetic blockade to interrupt of vagal transmission in experimental designs.

Original language	English
Pages (from-to)	53-56
Number of pages	4
Journal	Scandinavian Journal of Laboratory Animal Science
Volume	30
Issue number	2
DOIs	https://doi.org/10.23675/sjlas.v30i2.41
Publication status	Published - 1 Dec 2003

Scopus Subject Areas

Animal Science and Zoology
Biochemistry, Genetics and Molecular Biology(all)
veterinary(all)

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abstract = "The effect of vagal nerve blockade by epineural application of lignocaine was studied in the rat. Vagal nerve conduction was assessed by subdiaphragmatic esophageal electromyogram (EMG) response evoked by stimulation of the cervical vagus nerve. It was found that epineural application of lignocaine completely blocked the evoked EMG response within one minute. After washing away the anesthetic, recovery of nerve conduction was gradual, taking approximately 60 min. Our results have implications for the use of local anesthetic blockade to interrupt of vagal transmission in experimental designs.",

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N2 - The effect of vagal nerve blockade by epineural application of lignocaine was studied in the rat. Vagal nerve conduction was assessed by subdiaphragmatic esophageal electromyogram (EMG) response evoked by stimulation of the cervical vagus nerve. It was found that epineural application of lignocaine completely blocked the evoked EMG response within one minute. After washing away the anesthetic, recovery of nerve conduction was gradual, taking approximately 60 min. Our results have implications for the use of local anesthetic blockade to interrupt of vagal transmission in experimental designs.

AB - The effect of vagal nerve blockade by epineural application of lignocaine was studied in the rat. Vagal nerve conduction was assessed by subdiaphragmatic esophageal electromyogram (EMG) response evoked by stimulation of the cervical vagus nerve. It was found that epineural application of lignocaine completely blocked the evoked EMG response within one minute. After washing away the anesthetic, recovery of nerve conduction was gradual, taking approximately 60 min. Our results have implications for the use of local anesthetic blockade to interrupt of vagal transmission in experimental designs.

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Evaluation of vagal nerve blockade with epineural lignocaine application

Abstract

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