Ethnobotanical approach versus random approach in the search for new bioactive compounds: Support of a hypothesis

C. Gyllenhaal, M. R. Kadushin, B. Southavong, K. Sydara, S. Bouamanivong, M. Xaiveu, L. T. Xuan, N. T. Hiep, N. V. Hung, P. K. Loc, L. X. Dac, T. Q. Bich, N. M. Cuong, H. M. Ly, Hongjie ZHANG, S. G. Franzblau, H. Xie, M. C. Riley, B. G. Elkington, H. T. NguyenD. P. Waller, C. Y. Ma, P. Tamez, G. T. Tan, J. M. Pezzuto, D. D. Soejarto*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Context: Whether natural product drug discovery programs should rely on wild plants collected "randomly" from the natural environment, or whether they should also include plants collected on the basis of use in traditional medicine remains an open question. Objective: This study analyzes whether plants with ethnomedical uses from Vietnam and Laos have a higher hit rate in bioassay testing than plants collected from a national park in Vietnam with the goal of maximizing taxonomic diversity ("random" collection). Materials and Methods: All plants were extracted and subjected to bioassay in the same laboratories. Results of assays of plant collections and plant parts (samples) were scored as active or inactive based on whether any extracts had a positive result in a bioassay. Contingency tables were analyzed using χ 2 statistics. Results: Random collections had a higher hit rate than ethnomedical collections, but for samples, ethnomedical plants were more likely to be active. Ethnomedical collections and samples had higher hit rates for tuberculosis, while samples, but not collections, had a higher hit rate for malaria. Little evidence was found to support an advantage for ethnomedical plants in HIV, chemoprevention and cancer bioassays. Plants whose ethnomedical uses directly correlated to a bioassay did not have a significantly higher hit rate than random plants. Discussion: Plants with ethnomedical uses generally had a higher rate of activity in some drug discovery bioassays, but the assays did not directly confirm specific uses. Conclusions: Ethnomedical uses may contribute to a higher rate of activity in drug discovery screening.

Original languageEnglish
Pages (from-to)30-41
Number of pages12
JournalPharmaceutical Biology
Volume50
Issue number1
DOIs
Publication statusPublished - Jan 2012

Scopus Subject Areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

User-Defined Keywords

  • Cancer
  • Chemoprevention
  • Drug discovery
  • HIV
  • Laos
  • Malaria
  • Screening
  • Traditional medicine
  • Tuberculosis
  • Vietnam

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