Abstract
In this article, we propose a new method for estimating the number of equal components m 0 of two m-dimensional population means when m is large. The proposed method can be used to estimate the number of equally expressed or differentially expressed genes in DNA microarray studies. It can also be applied in the step of estimating m 0 in adaptive false discovery rate controlling procedures. Simulation results show that the bias of the moment estimator is very small for both normal and non normal data. It has higher precision than existing methods in most cases. It has more evident advantage under non normal data.
| Original language | English |
|---|---|
| Pages (from-to) | 4617-4638 |
| Number of pages | 22 |
| Journal | Communications in Statistics - Theory and Methods |
| Volume | 50 |
| Issue number | 19 |
| Early online date | 12 Feb 2020 |
| DOIs | |
| Publication status | Published - 31 Aug 2021 |
User-Defined Keywords
- DNA microarray analysis
- false discovery rate
- high-dimensional data
- Multiple hypothesis testing