Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches

Md. Sahab Uddin, Abdullah Al Mamun, Badrah S. Alghamdi, Devesh Tewari, Philippe Jeandet, Md. Shahid Sarwar, Ghulam Md. Ashraf*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Glioblastoma multiforme (GBM) is the most common form of brain cancer and one of the most aggressive cancers found in humans. Most of the signs and symptoms of GBM can be mild and slowly aggravated, although other symptoms might demonstrate it as an acute ailment. However, the precise mechanisms of the development of GBM remain unknown. Due to the improvement of molecular pathology, current researches have reported that glioma progression is strongly connected with different types of epigenetic phenomena, such as histone modifications, DNA methylation, chromatin remodeling, and aberrant microRNA. Furthermore, the genes and the proteins that control these alterations have become novel targets for treating glioma because of the reversibility of epigenetic modifications. In some cases, gene mutations including P16, TP53, and EGFR, have been observed in GBM. In contrast, monosomies, including removals of chromosome 10, particularly q23 and q25–26, are considered the standard markers for determining the development and aggressiveness of GBM. Recently, amid the epigenetic therapies, histone deacetylase inhibitors (HDACIs) and DNA methyltransferase inhibitors have been used for treating tumors, either single or combined. Specifically, HDACIs are served as a good choice and deliver a novel pathway to treat GBM. In this review, we focus on the epigenetics of GBM and the consequence of its mutations. We also highlight various treatment approaches, namely gene editing, epigenetic drugs, and microRNAs to combat GBM.

Original languageEnglish
Pages (from-to)100-120
Number of pages21
JournalSeminars in Cancer Biology
Volume83
Early online date25 Dec 2020
DOIs
Publication statusPublished - Aug 2022

Scopus Subject Areas

  • Cancer Research

User-Defined Keywords

  • Chromatin remodeling
  • DNA methylation
  • Epigenetics
  • Glioblastoma
  • Histone deacetylase inhibitors

Fingerprint

Dive into the research topics of 'Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches'. Together they form a unique fingerprint.

Cite this