Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy

Yuanjun Lu, Yau Tuen Chan, Hor Yue Tan, Sha Li, Ning Wang*, Yibin Feng*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

249 Citations (Scopus)

Abstract

Epigenetics is dynamic and heritable modifications to the genome that occur independently of DNA sequence. It requires interactions cohesively with various enzymes and other molecular components. Aberrant epigenetic alterations can lead to inappropriate onset of genetic expressions and promote tumorigenesis. As the epigenetic modifiers are susceptible to extrinsic factors and reversible, they are becoming promising targets in multiple cancer therapies. Recently, various epi-drugs have been developed and implicated in clinical use. The use of epi-drugs alone, or in combination with chemotherapy or immunotherapy, has shown compelling outcomes, including augmentation of anti-tumoral effects, overcoming drug resistance, and activation of host immune response.

Original languageEnglish
Article number79
Number of pages16
JournalMolecular Cancer
Volume19
DOIs
Publication statusPublished - 27 Apr 2020

Scopus Subject Areas

  • Molecular Medicine
  • Oncology
  • Cancer Research

User-Defined Keywords

  • Cancer
  • Combination strategy
  • Epi-drugs
  • Epigenetic modification
  • Tumour microenvironment

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