Epigenetic modulation by inorganic metal complexes

Chung Hang Leung*, Li Juan Liu, Ka Ho Leung, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)
1 Downloads (Pure)

Abstract

Epigenetic mechanisms have emerged as key targets for therapeutic intervention. However, while a number of organic small-molecular "epidrugs" have been approved for clinical use, no metal-based epigenetic modulator have been successfully approved. Metal complexes exhibit a variety of distinct properties that make them viable alternatives to organic molecules as therapeutic agents. In this review, we highlight recent examples of epigenetic modulation by metal complexes, with a view towards showcasing the different mechanisms exploited by metal complexes for targeting either epigenetic marks or epigenetic pathways for potential therapeutic applications.

Original languageEnglish
Pages (from-to)25-34
Number of pages10
JournalCoordination Chemistry Reviews
Volume319
DOIs
Publication statusPublished - 15 Jul 2016

Scopus Subject Areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

User-Defined Keywords

  • Chromatin-modifying enzymes
  • Epidrugs
  • Epigenetic
  • Histone
  • Transition metal complexes

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