@article{5aa27c5e22284d0e9b4cbc20f1103d8b,
title = "Epigenetic modulation by inorganic metal complexes",
abstract = "Epigenetic mechanisms have emerged as key targets for therapeutic intervention. However, while a number of organic small-molecular {"}epidrugs{"} have been approved for clinical use, no metal-based epigenetic modulator have been successfully approved. Metal complexes exhibit a variety of distinct properties that make them viable alternatives to organic molecules as therapeutic agents. In this review, we highlight recent examples of epigenetic modulation by metal complexes, with a view towards showcasing the different mechanisms exploited by metal complexes for targeting either epigenetic marks or epigenetic pathways for potential therapeutic applications.",
keywords = "Chromatin-modifying enzymes, Epidrugs, Epigenetic, Histone, Transition metal complexes",
author = "Leung, {Chung Hang} and Liu, {Li Juan} and Leung, {Ka Ho} and Ma, {Edmond Dik Lung}",
note = "Funding Information: This work is supported by Hong Kong Baptist University ( FRG2/14-15/004 and FRG2/15-16/002 ), the Health and Medical Research Fund ( HMRF/14130522 ), the Research Grants Council ( HKBU/201811 , HKBU/204612 and HKBU/201913 ), the French Agence Nationale de la Recherche/Research Grants Council Joint Research Scheme ( AHKBU201/12 ; Oligoswitch ANR-12-IS07-0001 ), National Natural Science Foundation of China ( 21575121 ), Guangdong Province Natural Science Foundation ( 2015A030313816 ), Hong Kong Baptist University Century Club Sponsorship Scheme 2015, Interdisciplinary Research Matching Scheme ( RC-IRMS/14-15/06 ), the Science and Technology Development Fund, Macao SAR ( 103/2012/A3 ), the University of Macau ( MYRG091(Y3-L2)-ICMS12-LCH , MYRG2015-00137-ICMS-QRCM , MRG023/LCH/2013/ICMS and MRG044/LCH/2015/ICMS ).",
year = "2016",
month = jul,
day = "15",
doi = "10.1016/j.ccr.2016.03.014",
language = "English",
volume = "319",
pages = "25--34",
journal = "Coordination Chemistry Reviews",
issn = "0010-8545",
publisher = "Elsevier B.V.",
}