Epigenetic modulation by inorganic metal complexes

Chung Hang Leung; Li Juan Liu; Ka Ho Leung; Edmond Dik Lung Ma

doi:10.1016/j.ccr.2016.03.014

Epigenetic modulation by inorganic metal complexes

Chung Hang Leung^*, Li Juan Liu, Ka Ho Leung, Edmond Dik Lung Ma^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

15 Citations (Scopus)

29 Downloads (Pure)

Abstract

Epigenetic mechanisms have emerged as key targets for therapeutic intervention. However, while a number of organic small-molecular "epidrugs" have been approved for clinical use, no metal-based epigenetic modulator have been successfully approved. Metal complexes exhibit a variety of distinct properties that make them viable alternatives to organic molecules as therapeutic agents. In this review, we highlight recent examples of epigenetic modulation by metal complexes, with a view towards showcasing the different mechanisms exploited by metal complexes for targeting either epigenetic marks or epigenetic pathways for potential therapeutic applications.

Original language	English
Pages (from-to)	25-34
Number of pages	10
Journal	Coordination Chemistry Reviews
Volume	319
DOIs	https://doi.org/10.1016/j.ccr.2016.03.014
Publication status	Published - 15 Jul 2016

Scopus Subject Areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

User-Defined Keywords

Chromatin-modifying enzymes
Epidrugs
Epigenetic
Histone
Transition metal complexes

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10.1016/j.ccr.2016.03.014

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title = "Epigenetic modulation by inorganic metal complexes",

abstract = "Epigenetic mechanisms have emerged as key targets for therapeutic intervention. However, while a number of organic small-molecular {"}epidrugs{"} have been approved for clinical use, no metal-based epigenetic modulator have been successfully approved. Metal complexes exhibit a variety of distinct properties that make them viable alternatives to organic molecules as therapeutic agents. In this review, we highlight recent examples of epigenetic modulation by metal complexes, with a view towards showcasing the different mechanisms exploited by metal complexes for targeting either epigenetic marks or epigenetic pathways for potential therapeutic applications.",

keywords = "Chromatin-modifying enzymes, Epidrugs, Epigenetic, Histone, Transition metal complexes",

author = "Leung, {Chung Hang} and Liu, {Li Juan} and Leung, {Ka Ho} and Ma, {Edmond Dik Lung}",

note = "Funding Information: This work is supported by Hong Kong Baptist University ( FRG2/14-15/004 and FRG2/15-16/002 ), the Health and Medical Research Fund ( HMRF/14130522 ), the Research Grants Council ( HKBU/201811 , HKBU/204612 and HKBU/201913 ), the French Agence Nationale de la Recherche/Research Grants Council Joint Research Scheme ( AHKBU201/12 ; Oligoswitch ANR-12-IS07-0001 ), National Natural Science Foundation of China ( 21575121 ), Guangdong Province Natural Science Foundation ( 2015A030313816 ), Hong Kong Baptist University Century Club Sponsorship Scheme 2015, Interdisciplinary Research Matching Scheme ( RC-IRMS/14-15/06 ), the Science and Technology Development Fund, Macao SAR ( 103/2012/A3 ), the University of Macau ( MYRG091(Y3-L2)-ICMS12-LCH , MYRG2015-00137-ICMS-QRCM , MRG023/LCH/2013/ICMS and MRG044/LCH/2015/ICMS ).",

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doi = "10.1016/j.ccr.2016.03.014",

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AU - Leung, Chung Hang

AU - Liu, Li Juan

AU - Leung, Ka Ho

AU - Ma, Edmond Dik Lung

N1 - Funding Information: This work is supported by Hong Kong Baptist University ( FRG2/14-15/004 and FRG2/15-16/002 ), the Health and Medical Research Fund ( HMRF/14130522 ), the Research Grants Council ( HKBU/201811 , HKBU/204612 and HKBU/201913 ), the French Agence Nationale de la Recherche/Research Grants Council Joint Research Scheme ( AHKBU201/12 ; Oligoswitch ANR-12-IS07-0001 ), National Natural Science Foundation of China ( 21575121 ), Guangdong Province Natural Science Foundation ( 2015A030313816 ), Hong Kong Baptist University Century Club Sponsorship Scheme 2015, Interdisciplinary Research Matching Scheme ( RC-IRMS/14-15/06 ), the Science and Technology Development Fund, Macao SAR ( 103/2012/A3 ), the University of Macau ( MYRG091(Y3-L2)-ICMS12-LCH , MYRG2015-00137-ICMS-QRCM , MRG023/LCH/2013/ICMS and MRG044/LCH/2015/ICMS ).

PY - 2016/7/15

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N2 - Epigenetic mechanisms have emerged as key targets for therapeutic intervention. However, while a number of organic small-molecular "epidrugs" have been approved for clinical use, no metal-based epigenetic modulator have been successfully approved. Metal complexes exhibit a variety of distinct properties that make them viable alternatives to organic molecules as therapeutic agents. In this review, we highlight recent examples of epigenetic modulation by metal complexes, with a view towards showcasing the different mechanisms exploited by metal complexes for targeting either epigenetic marks or epigenetic pathways for potential therapeutic applications.

AB - Epigenetic mechanisms have emerged as key targets for therapeutic intervention. However, while a number of organic small-molecular "epidrugs" have been approved for clinical use, no metal-based epigenetic modulator have been successfully approved. Metal complexes exhibit a variety of distinct properties that make them viable alternatives to organic molecules as therapeutic agents. In this review, we highlight recent examples of epigenetic modulation by metal complexes, with a view towards showcasing the different mechanisms exploited by metal complexes for targeting either epigenetic marks or epigenetic pathways for potential therapeutic applications.

KW - Chromatin-modifying enzymes

KW - Epidrugs

KW - Epigenetic

KW - Histone

KW - Transition metal complexes

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DO - 10.1016/j.ccr.2016.03.014

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AN - SCOPUS:84964887568

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VL - 319

SP - 25

EP - 34

JO - Coordination Chemistry Reviews

JF - Coordination Chemistry Reviews

ER -

Epigenetic modulation by inorganic metal complexes

Abstract

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