Abstract
Epigenetic mechanisms have emerged as key targets for therapeutic intervention. However, while a number of organic small-molecular "epidrugs" have been approved for clinical use, no metal-based epigenetic modulator have been successfully approved. Metal complexes exhibit a variety of distinct properties that make them viable alternatives to organic molecules as therapeutic agents. In this review, we highlight recent examples of epigenetic modulation by metal complexes, with a view towards showcasing the different mechanisms exploited by metal complexes for targeting either epigenetic marks or epigenetic pathways for potential therapeutic applications.
Original language | English |
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Pages (from-to) | 25-34 |
Number of pages | 10 |
Journal | Coordination Chemistry Reviews |
Volume | 319 |
DOIs | |
Publication status | Published - 15 Jul 2016 |
Scopus Subject Areas
- Physical and Theoretical Chemistry
- Inorganic Chemistry
- Materials Chemistry
User-Defined Keywords
- Chromatin-modifying enzymes
- Epidrugs
- Epigenetic
- Histone
- Transition metal complexes