Enzyme free glucose sensing by amino-functionalized silicon quantum dot

Liqing Du; Zhongping Li; Jiaoli Yao; Guangming Wen; Chuan Dong; Hung Wing Li

doi:10.1016/j.saa.2019.03.071

Enzyme free glucose sensing by amino-functionalized silicon quantum dot

Liqing Du, Zhongping Li^*, Jiaoli Yao, Guangming Wen, Chuan Dong, Hung Wing Li

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

30 Citations (Scopus)

Abstract

Silicon quantum dots have become one of the most popular nanomaterials in biological applications for their excellent biocompatibility and optical properties. Herein, we synthesized amino-functionalized silicon quantum dots (NH ₂ @SiQDs) via a simple microemulsion method, in which silicon tetrachloride and allylamine were used as source of silicon and functional group. NH ₂ @SiQDs exhibits good water-solubility, high fluorescence quantum yield and optical stability. A non-enzymatic biosensor of glucose was developed based on the fluorescence quenching of NH ₂ @SiQDs in response to glucose. The fluorescence response was linearly proportional to glucose in the concentration range of 1.0 × 10 ⁻⁶ –9.0 × 10 ⁻⁵ mol/L and the detection limit was determined to be 3.0 × 10 ⁻⁷ mol/L. The developed glucose sensor was successfully applied in blood glucose analysis of human serum. Satisfactory result that agreed very well with traditional method was obtained.

Original language	English
Pages (from-to)	303-309
Number of pages	7
Journal	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume	216
DOIs	https://doi.org/10.1016/j.saa.2019.03.071
Publication status	Published - 5 Jun 2019

User-Defined Keywords

A glucose sensor
Enzyme free
Fluorescence quenching
Silicon quantum dots

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10.1016/j.saa.2019.03.071

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@article{1ab74bbdbc844540ba29fadb39bb3889,

title = "Enzyme free glucose sensing by amino-functionalized silicon quantum dot",

abstract = " Silicon quantum dots have become one of the most popular nanomaterials in biological applications for their excellent biocompatibility and optical properties. Herein, we synthesized amino-functionalized silicon quantum dots (NH 2 @SiQDs) via a simple microemulsion method, in which silicon tetrachloride and allylamine were used as source of silicon and functional group. NH 2 @SiQDs exhibits good water-solubility, high fluorescence quantum yield and optical stability. A non-enzymatic biosensor of glucose was developed based on the fluorescence quenching of NH 2 @SiQDs in response to glucose. The fluorescence response was linearly proportional to glucose in the concentration range of 1.0 × 10 −6 –9.0 × 10 −5 mol/L and the detection limit was determined to be 3.0 × 10 −7 mol/L. The developed glucose sensor was successfully applied in blood glucose analysis of human serum. Satisfactory result that agreed very well with traditional method was obtained.",

keywords = "A glucose sensor, Enzyme free, Fluorescence quenching, Silicon quantum dots",

author = "Liqing Du and Zhongping Li and Jiaoli Yao and Guangming Wen and Chuan Dong and Li, {Hung Wing}",

note = "Funding Information: This work was financially supported by Shanxi Hundred Talent Program (2015), research project supported by Shanxi Scholarship Council of China (2016-8) and the National Natural Science Foundation of China (21707082 and 21575083). We also thank the financial support of the Hong Kong Baptist University (FRG2/17-18/059).",

year = "2019",

month = jun,

day = "5",

doi = "10.1016/j.saa.2019.03.071",

language = "English",

volume = "216",

pages = "303--309",

journal = "Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy",

issn = "1386-1425",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Enzyme free glucose sensing by amino-functionalized silicon quantum dot

AU - Du, Liqing

AU - Li, Zhongping

AU - Yao, Jiaoli

AU - Wen, Guangming

AU - Dong, Chuan

AU - Li, Hung Wing

N1 - Funding Information: This work was financially supported by Shanxi Hundred Talent Program (2015), research project supported by Shanxi Scholarship Council of China (2016-8) and the National Natural Science Foundation of China (21707082 and 21575083). We also thank the financial support of the Hong Kong Baptist University (FRG2/17-18/059).

PY - 2019/6/5

Y1 - 2019/6/5

N2 - Silicon quantum dots have become one of the most popular nanomaterials in biological applications for their excellent biocompatibility and optical properties. Herein, we synthesized amino-functionalized silicon quantum dots (NH 2 @SiQDs) via a simple microemulsion method, in which silicon tetrachloride and allylamine were used as source of silicon and functional group. NH 2 @SiQDs exhibits good water-solubility, high fluorescence quantum yield and optical stability. A non-enzymatic biosensor of glucose was developed based on the fluorescence quenching of NH 2 @SiQDs in response to glucose. The fluorescence response was linearly proportional to glucose in the concentration range of 1.0 × 10 −6 –9.0 × 10 −5 mol/L and the detection limit was determined to be 3.0 × 10 −7 mol/L. The developed glucose sensor was successfully applied in blood glucose analysis of human serum. Satisfactory result that agreed very well with traditional method was obtained.

AB - Silicon quantum dots have become one of the most popular nanomaterials in biological applications for their excellent biocompatibility and optical properties. Herein, we synthesized amino-functionalized silicon quantum dots (NH 2 @SiQDs) via a simple microemulsion method, in which silicon tetrachloride and allylamine were used as source of silicon and functional group. NH 2 @SiQDs exhibits good water-solubility, high fluorescence quantum yield and optical stability. A non-enzymatic biosensor of glucose was developed based on the fluorescence quenching of NH 2 @SiQDs in response to glucose. The fluorescence response was linearly proportional to glucose in the concentration range of 1.0 × 10 −6 –9.0 × 10 −5 mol/L and the detection limit was determined to be 3.0 × 10 −7 mol/L. The developed glucose sensor was successfully applied in blood glucose analysis of human serum. Satisfactory result that agreed very well with traditional method was obtained.

KW - A glucose sensor

KW - Enzyme free

KW - Fluorescence quenching

KW - Silicon quantum dots

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U2 - 10.1016/j.saa.2019.03.071

DO - 10.1016/j.saa.2019.03.071

M3 - Journal article

C2 - 30909086

AN - SCOPUS:85063114207

SN - 1386-1425

VL - 216

SP - 303

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JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

ER -

Enzyme free glucose sensing by amino-functionalized silicon quantum dot

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