Enzyme free glucose sensing by amino-functionalized silicon quantum dot

Liqing Du, Zhongping Li*, Jiaoli Yao, Guangming Wen, Chuan Dong, Hung Wing LI

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

21 Citations (Scopus)


Silicon quantum dots have become one of the most popular nanomaterials in biological applications for their excellent biocompatibility and optical properties. Herein, we synthesized amino-functionalized silicon quantum dots (NH 2 @SiQDs) via a simple microemulsion method, in which silicon tetrachloride and allylamine were used as source of silicon and functional group. NH 2 @SiQDs exhibits good water-solubility, high fluorescence quantum yield and optical stability. A non-enzymatic biosensor of glucose was developed based on the fluorescence quenching of NH 2 @SiQDs in response to glucose. The fluorescence response was linearly proportional to glucose in the concentration range of 1.0 × 10 −6 –9.0 × 10 −5 mol/L and the detection limit was determined to be 3.0 × 10 −7 mol/L. The developed glucose sensor was successfully applied in blood glucose analysis of human serum. Satisfactory result that agreed very well with traditional method was obtained.

Original languageEnglish
Pages (from-to)303-309
Number of pages7
JournalSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Publication statusPublished - 5 Jun 2019

Scopus Subject Areas

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Spectroscopy

User-Defined Keywords

  • A glucose sensor
  • Enzyme free
  • Fluorescence quenching
  • Silicon quantum dots


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