ent-Kaurene diterpenoids from Isodon oresbius

Wei Xiang; Rong Tao Li; Zong Yu Wang; Sheng Hong Li; Qin Shi Zhao; Hong Jie Zhang; Han Dong Sun

doi:10.1016/j.phytochem.2004.02.022

ent-Kaurene diterpenoids from Isodon oresbius

Wei Xiang, Rong Tao Li, Zong Yu Wang, Sheng Hong Li, Qin Shi Zhao, Hong Jie Zhang, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

26 Citations (Scopus)

Abstract

Three new ent-kaurene diterpenoids, oreskaurins A-C (1-3), together with ten known ent-kaurene diterpenoids, enmenin monoacetate (4), effusanin E (5), adenolin B (6), maoecrystal G (7), enmelol (8), trichokaurin (9), sodoponin (10), trichorabdal A (11), nodosin (12), enmein (13), and a flavonoid, vitexin (14), were isolated from Isodon oresbius. Their structures were determined by spectroscopic means. Compound 12 showed inhibitory activity toward K562 cells with IC₅₀=1.43 μg/ml.

Three new ent-kaurene diterpenoids, oreskaurins A–C (1–3), and eleven known compounds were isolated from Isodon oresbius.

Original language	English
Pages (from-to)	1173-1177
Number of pages	5
Journal	Phytochemistry
Volume	65
Issue number	8
DOIs	https://doi.org/10.1016/j.phytochem.2004.02.022
Publication status	Published - Apr 2004

User-Defined Keywords

Cytotoxicity
ent-Kaurenoid
Isodon oresbius
Labiatae
Oreskaurins A-C

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10.1016/j.phytochem.2004.02.022

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@article{0e0ee5b8f8bb45198c968656399e795a,

title = "ent-Kaurene diterpenoids from Isodon oresbius",

abstract = "Three new ent-kaurene diterpenoids, oreskaurins A-C (1-3), together with ten known ent-kaurene diterpenoids, enmenin monoacetate (4), effusanin E (5), adenolin B (6), maoecrystal G (7), enmelol (8), trichokaurin (9), sodoponin (10), trichorabdal A (11), nodosin (12), enmein (13), and a flavonoid, vitexin (14), were isolated from Isodon oresbius. Their structures were determined by spectroscopic means. Compound 12 showed inhibitory activity toward K562 cells with IC50=1.43 μg/ml.Three new ent-kaurene diterpenoids, oreskaurins A–C (1–3), and eleven known compounds were isolated from Isodon oresbius.",

keywords = "Cytotoxicity, ent-Kaurenoid, Isodon oresbius, Labiatae, Oreskaurins A-C",

author = "Wei Xiang and Li, {Rong Tao} and Wang, {Zong Yu} and Li, {Sheng Hong} and Zhao, {Qin Shi} and Zhang, {Hong Jie} and Sun, {Han Dong}",

year = "2004",

month = apr,

doi = "10.1016/j.phytochem.2004.02.022",

language = "English",

volume = "65",

pages = "1173--1177",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd.",

number = "8",

}

TY - JOUR

T1 - ent-Kaurene diterpenoids from Isodon oresbius

AU - Xiang, Wei

AU - Li, Rong Tao

AU - Wang, Zong Yu

AU - Li, Sheng Hong

AU - Zhao, Qin Shi

AU - Zhang, Hong Jie

AU - Sun, Han Dong

PY - 2004/4

Y1 - 2004/4

N2 - Three new ent-kaurene diterpenoids, oreskaurins A-C (1-3), together with ten known ent-kaurene diterpenoids, enmenin monoacetate (4), effusanin E (5), adenolin B (6), maoecrystal G (7), enmelol (8), trichokaurin (9), sodoponin (10), trichorabdal A (11), nodosin (12), enmein (13), and a flavonoid, vitexin (14), were isolated from Isodon oresbius. Their structures were determined by spectroscopic means. Compound 12 showed inhibitory activity toward K562 cells with IC50=1.43 μg/ml.Three new ent-kaurene diterpenoids, oreskaurins A–C (1–3), and eleven known compounds were isolated from Isodon oresbius.

AB - Three new ent-kaurene diterpenoids, oreskaurins A-C (1-3), together with ten known ent-kaurene diterpenoids, enmenin monoacetate (4), effusanin E (5), adenolin B (6), maoecrystal G (7), enmelol (8), trichokaurin (9), sodoponin (10), trichorabdal A (11), nodosin (12), enmein (13), and a flavonoid, vitexin (14), were isolated from Isodon oresbius. Their structures were determined by spectroscopic means. Compound 12 showed inhibitory activity toward K562 cells with IC50=1.43 μg/ml.Three new ent-kaurene diterpenoids, oreskaurins A–C (1–3), and eleven known compounds were isolated from Isodon oresbius.

KW - Cytotoxicity

KW - ent-Kaurenoid

KW - Isodon oresbius

KW - Labiatae

KW - Oreskaurins A-C

UR - http://www.scopus.com/inward/record.url?scp=2142659290&partnerID=8YFLogxK

U2 - 10.1016/j.phytochem.2004.02.022

DO - 10.1016/j.phytochem.2004.02.022

M3 - Journal article

C2 - 15110700

AN - SCOPUS:2142659290

SN - 0031-9422

VL - 65

SP - 1173

EP - 1177

JO - Phytochemistry

JF - Phytochemistry

IS - 8

ER -

ent-Kaurene diterpenoids from Isodon oresbius

Abstract

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