Three new ent-kaurene diterpenoids, oreskaurins A-C (1-3), together with ten known ent-kaurene diterpenoids, enmenin monoacetate (4), effusanin E (5), adenolin B (6), maoecrystal G (7), enmelol (8), trichokaurin (9), sodoponin (10), trichorabdal A (11), nodosin (12), enmein (13), and a flavonoid, vitexin (14), were isolated from Isodon oresbius. Their structures were determined by spectroscopic means. Compound 12 showed inhibitory activity toward K562 cells with IC50=1.43 μg/ml.
Three new ent-kaurene diterpenoids, oreskaurins A–C (1–3), and eleven known compounds were isolated from Isodon oresbius.
|Number of pages||5|
|Publication status||Published - Apr 2004|
Scopus Subject Areas
- Molecular Biology
- Plant Science
- Isodon oresbius
- Oreskaurins A-C