Three new ent-kaurene diterpenoids, adenanthins N, O and P (1-3), and four known diterpenoids, leucophyllin E (4), glabcensin C (5), adenanthin A (6), leucophyllin 8 (7), together with a highly unsaturated fatty acid, 9,16-dioxo-10,12,14-octadeca-trienoic acid (8), were isolated from Isodon adenanthus (Diels) Kudo. The structure of compound 4 was revised accordingly. Compound 1 showed significant cytotoxic activity against K562 cells with IC50 = 0.45 μg/mL.
|Number of pages||4|
|Journal||Journal of Integrative Plant Biology|
|Publication status||Published - Nov 2003|
- Isodon adenanthus
- adenanthins N, O and P