ent-Kaurane diterpenoids from Isodon scoparius

Yong Zhao, Jian Xin Pu, Sheng Xiong Huang, Ying Li Wu, Li Bin Yang, Wei Lie Xiao, Quan Bin Han, Guo Qiang Chen, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

16 Citations (Scopus)


Nine new ent-kaurane diterpenoids, isoscoparins D-L (1-9), and an artificial product, the acetonide of rabdoloxin A (10), along with 16 known analogues (11-26), were isolated from the leaves of Isodon scoparius. The new structures were determined by 1D and 2D NMR spectroscopic analysis. Selected compounds were evaluated for their cytotoxicity against NB4, A549, PC-3, MCF-7, and SH-SY5Y cell lines.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalJournal of Natural Products
Issue number1
Early online date11 Dec 2008
Publication statusPublished - 23 Jan 2009

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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