Ent-Kaurane Diterpenoids from Isodon rubescens var. lushiensis

Quanbin Han, Shenghong Li, Liyan Peng, Handong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

18 Citations (Scopus)


Three new 6,7-seco-6,19:6,20-diepoxy-1α,7-olide-ent-kaurane diterpenoids, ludongnins C-E (1-3), along with six known analogs, macrocalyxoformins A (4) and B (5), sculponeatins A (6) and B (7), and ludongnins A (8) and B (9), were isolated from Isodon rubescens var. lushiensis. The structures of the new compounds were determined on the basis of the spectroscopic evidences. Compound (5) exhibited significant inhibitory activities against the Bcap37 and K562 cell lines with IC50 = 0.82 and 0.62 μg/mL, respectively.

Original languageEnglish
Pages (from-to)933-938
Number of pages6
Issue number4
Early online date4 Feb 2003
Publication statusPublished - 1 Apr 2003

Scopus Subject Areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry


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