Ent-kaurane diterpenoids from Isodon rubescens var. lushanensis

Quan Bin Han; Ma Lin Li; Sheng Hong Li; Yi Kun Mou; Zhong Wen Lin; Han Dong Sun

doi:10.1248/cpb.51.790

Ent-kaurane diterpenoids from Isodon rubescens var. lushanensis

Quan Bin Han, Ma Lin Li, Sheng Hong Li, Yi Kun Mou, Zhong Wen Lin, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

85 Citations (Scopus)

Abstract

Four new ent-kaurane diterpenoids lushanrubescensins F-I (1-4), together with 11 known ones, lasiodonin (5), oridonin (6), ponicidin (7), isodonoiol (8), isodonal (9), rabdosin B (10), rabdoternins A and B (11 and 12), enmenol (13), epinodosin (14), and inflexusin (15), were isolated from Isodon rubescens var. lushanensis, and the structures were elucidated by spectroscopic analysis. The inhibitory effect against the K562, Bcap37, BGC823, BIU87, CA, CNE, and Hela cell lines of compounds 3 and 5-10 were evaluated.

Original language	English
Pages (from-to)	790-793
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	51
Issue number	7
DOIs	https://doi.org/10.1248/cpb.51.790
Publication status	Published - Jul 2003

Scopus Subject Areas

General Chemistry
Drug Discovery

User-Defined Keywords

Cytotoxity
ent-kauranoid
Isodon rubescens var. lushanensis
Labiatae
Lushanrubescensin F
Lushanrubescensin I

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10.1248/cpb.51.790

Cite this

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title = "Ent-kaurane diterpenoids from Isodon rubescens var. lushanensis",

abstract = "Four new ent-kaurane diterpenoids lushanrubescensins F-I (1-4), together with 11 known ones, lasiodonin (5), oridonin (6), ponicidin (7), isodonoiol (8), isodonal (9), rabdosin B (10), rabdoternins A and B (11 and 12), enmenol (13), epinodosin (14), and inflexusin (15), were isolated from Isodon rubescens var. lushanensis, and the structures were elucidated by spectroscopic analysis. The inhibitory effect against the K562, Bcap37, BGC823, BIU87, CA, CNE, and Hela cell lines of compounds 3 and 5-10 were evaluated.",

keywords = "Cytotoxity, ent-kauranoid, Isodon rubescens var. lushanensis, Labiatae, Lushanrubescensin F, Lushanrubescensin I",

author = "Han, {Quan Bin} and Li, {Ma Lin} and Li, {Sheng Hong} and Mou, {Yi Kun} and Lin, {Zhong Wen} and Sun, {Han Dong}",

year = "2003",

month = jul,

doi = "10.1248/cpb.51.790",

language = "English",

volume = "51",

pages = "790--793",

journal = "Chemical and Pharmaceutical Bulletin",

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publisher = "Pharmaceutical Society of Japan",

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AU - Han, Quan Bin

AU - Li, Ma Lin

AU - Li, Sheng Hong

AU - Mou, Yi Kun

AU - Lin, Zhong Wen

AU - Sun, Han Dong

PY - 2003/7

Y1 - 2003/7

N2 - Four new ent-kaurane diterpenoids lushanrubescensins F-I (1-4), together with 11 known ones, lasiodonin (5), oridonin (6), ponicidin (7), isodonoiol (8), isodonal (9), rabdosin B (10), rabdoternins A and B (11 and 12), enmenol (13), epinodosin (14), and inflexusin (15), were isolated from Isodon rubescens var. lushanensis, and the structures were elucidated by spectroscopic analysis. The inhibitory effect against the K562, Bcap37, BGC823, BIU87, CA, CNE, and Hela cell lines of compounds 3 and 5-10 were evaluated.

AB - Four new ent-kaurane diterpenoids lushanrubescensins F-I (1-4), together with 11 known ones, lasiodonin (5), oridonin (6), ponicidin (7), isodonoiol (8), isodonal (9), rabdosin B (10), rabdoternins A and B (11 and 12), enmenol (13), epinodosin (14), and inflexusin (15), were isolated from Isodon rubescens var. lushanensis, and the structures were elucidated by spectroscopic analysis. The inhibitory effect against the K562, Bcap37, BGC823, BIU87, CA, CNE, and Hela cell lines of compounds 3 and 5-10 were evaluated.

KW - Cytotoxity

KW - ent-kauranoid

KW - Isodon rubescens var. lushanensis

KW - Labiatae

KW - Lushanrubescensin F

KW - Lushanrubescensin I

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DO - 10.1248/cpb.51.790

M3 - Journal article

SN - 0009-2363

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EP - 793

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 7

ER -

Ent-kaurane diterpenoids from Isodon rubescens var. lushanensis

Abstract

Scopus Subject Areas

User-Defined Keywords

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