ent-Kaurane diterpenoids from Isodon nervosus

Li Mei Li, Guo You Li, Li Sheng Ding, Li Bin Yang, Yong Zhao, Jian Xin Pu, Wei Lie Xiao, Quan Bin Han, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

20 Citations (Scopus)


A pentacyclic ent-kauranoid, nervonin A (1), with an unprecedented cyclobutane moiety in the structure, and nine other new ent-kaurane diterpenoids, nervonins B-J (2-10), along with 10 known ones (11-20), were isolated from Isodon nervosus. Their structures were elucidated by detailed spectroscopic analysis. All diterpenoids were assayed for their cytotoxicity against K562, A549, and HepG2 human cell lines. Compounds 2, 11, 16, 17, and 20 showed significant cytotoxicity.

Original languageEnglish
Pages (from-to)684-688
Number of pages5
JournalJournal of Natural Products
Issue number4
Early online date18 Mar 2008
Publication statusPublished - 1 Apr 2008

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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