ent-Kaurane diterpenoids from Isodon nervosus

Li Mei Li; Guo You Li; Li Sheng Ding; Li Bin Yang; Yong Zhao; Jian Xin Pu; Wei Lie Xiao; Quan Bin Han; Han Dong Sun

doi:10.1021/np800027a

ent-Kaurane diterpenoids from Isodon nervosus

Li Mei Li, Guo You Li, Li Sheng Ding, Li Bin Yang, Yong Zhao, Jian Xin Pu, Wei Lie Xiao, Quan Bin Han, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

20 Citations (Scopus)

Abstract

A pentacyclic ent-kauranoid, nervonin A (1), with an unprecedented cyclobutane moiety in the structure, and nine other new ent-kaurane diterpenoids, nervonins B-J (2-10), along with 10 known ones (11-20), were isolated from Isodon nervosus. Their structures were elucidated by detailed spectroscopic analysis. All diterpenoids were assayed for their cytotoxicity against K562, A549, and HepG2 human cell lines. Compounds 2, 11, 16, 17, and 20 showed significant cytotoxicity.

Original language	English
Pages (from-to)	684-688
Number of pages	5
Journal	Journal of Natural Products
Volume	71
Issue number	4
Early online date	18 Mar 2008
DOIs	https://doi.org/10.1021/np800027a
Publication status	Published - 1 Apr 2008

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10.1021/np800027a

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title = "ent-Kaurane diterpenoids from Isodon nervosus",

abstract = "A pentacyclic ent-kauranoid, nervonin A (1), with an unprecedented cyclobutane moiety in the structure, and nine other new ent-kaurane diterpenoids, nervonins B-J (2-10), along with 10 known ones (11-20), were isolated from Isodon nervosus. Their structures were elucidated by detailed spectroscopic analysis. All diterpenoids were assayed for their cytotoxicity against K562, A549, and HepG2 human cell lines. Compounds 2, 11, 16, 17, and 20 showed significant cytotoxicity.",

author = "Li, {Li Mei} and Li, {Guo You} and Ding, {Li Sheng} and Yang, {Li Bin} and Yong Zhao and Pu, {Jian Xin} and Xiao, {Wei Lie} and Han, {Quan Bin} and Sun, {Han Dong}",

note = "Financial support of this research was provided by the Natural Science Foundation of Yunnan Province (No. 2004C0008Z), the National Natural Science Foundation of China (No. 20502026 to Q.-B.H. and No. 30772637 to H.-D.S.), and the Major Direction Project Foundation of ACS (No. KSCX2-YW-R-25).",

year = "2008",

month = apr,

day = "1",

doi = "10.1021/np800027a",

language = "English",

volume = "71",

pages = "684--688",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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TY - JOUR

T1 - ent-Kaurane diterpenoids from Isodon nervosus

AU - Li, Li Mei

AU - Li, Guo You

AU - Ding, Li Sheng

AU - Yang, Li Bin

AU - Zhao, Yong

AU - Pu, Jian Xin

AU - Xiao, Wei Lie

AU - Han, Quan Bin

AU - Sun, Han Dong

N1 - Financial support of this research was provided by the Natural Science Foundation of Yunnan Province (No. 2004C0008Z), the National Natural Science Foundation of China (No. 20502026 to Q.-B.H. and No. 30772637 to H.-D.S.), and the Major Direction Project Foundation of ACS (No. KSCX2-YW-R-25).

PY - 2008/4/1

Y1 - 2008/4/1

N2 - A pentacyclic ent-kauranoid, nervonin A (1), with an unprecedented cyclobutane moiety in the structure, and nine other new ent-kaurane diterpenoids, nervonins B-J (2-10), along with 10 known ones (11-20), were isolated from Isodon nervosus. Their structures were elucidated by detailed spectroscopic analysis. All diterpenoids were assayed for their cytotoxicity against K562, A549, and HepG2 human cell lines. Compounds 2, 11, 16, 17, and 20 showed significant cytotoxicity.

AB - A pentacyclic ent-kauranoid, nervonin A (1), with an unprecedented cyclobutane moiety in the structure, and nine other new ent-kaurane diterpenoids, nervonins B-J (2-10), along with 10 known ones (11-20), were isolated from Isodon nervosus. Their structures were elucidated by detailed spectroscopic analysis. All diterpenoids were assayed for their cytotoxicity against K562, A549, and HepG2 human cell lines. Compounds 2, 11, 16, 17, and 20 showed significant cytotoxicity.

UR - http://www.scopus.com/inward/record.url?scp=43249115100&partnerID=8YFLogxK

U2 - 10.1021/np800027a

DO - 10.1021/np800027a

M3 - Journal article

SN - 0163-3864

VL - 71

SP - 684

EP - 688

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

ent-Kaurane diterpenoids from Isodon nervosus

Abstract

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