ent-Abietane diterpenoids from Isodon rubescens var. rubescens

Sheng Xiong Huang; Jian Xin Pu; Wei Lie Xiao; Li Mei Li; Zhi Ying Weng; Yan Zhou; Quan Bin Han; Shu Lin Peng; Li Sheng Ding; Li Guang Lou; Han Dong Sun

doi:10.1016/j.phytochem.2006.11.007

ent-Abietane diterpenoids from Isodon rubescens var. rubescens

Sheng Xiong Huang
, Jian Xin Pu
, Wei Lie Xiao
, Li Mei Li
, Zhi Ying Weng
, Yan Zhou
, Quan Bin Han
, Shu Lin Peng
, Li Sheng Ding
, Li Guang Lou
, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

31 Citations (Scopus)

Abstract

ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC₅₀ value of 0.91 μM against A549 cells.

Original language	English
Pages (from-to)	616-622
Number of pages	7
Journal	Phytochemistry
Volume	68
Issue number	5
DOIs	https://doi.org/10.1016/j.phytochem.2006.11.007
Publication status	Published - Mar 2007

User-Defined Keywords

Cytotoxicity
Diterpenoid
ent-Abietane
Hebeiabinin
Isodon rubescens var. rubescens
Labiatae

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10.1016/j.phytochem.2006.11.007

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@article{10270716afff447c965cdb44eb8cf478,

title = "ent-Abietane diterpenoids from Isodon rubescens var. rubescens",

abstract = "ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC50 value of 0.91 μM against A549 cells.",

keywords = "Cytotoxicity, Diterpenoid, ent-Abietane, Hebeiabinin, Isodon rubescens var. rubescens, Labiatae",

author = "Huang, \{Sheng Xiong\} and Pu, \{Jian Xin\} and Xiao, \{Wei Lie\} and Li, \{Li Mei\} and Weng, \{Zhi Ying\} and Yan Zhou and Han, \{Quan Bin\} and Peng, \{Shu Lin\} and Ding, \{Li Sheng\} and Lou, \{Li Guang\} and Sun, \{Han Dong\}",

note = "Funding Information: This work was financially supported by the Natural Science Foundation of Yunnan Province (No. 2004C0008Z) and by the National Natural Science Foundation of China (No. 20502026 to Q.-B. Han.). The authors were grateful to Mrs. Xu Zou for collecting the plant material.",

year = "2007",

month = mar,

doi = "10.1016/j.phytochem.2006.11.007",

language = "English",

volume = "68",

pages = "616--622",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd.",

number = "5",

}

TY - JOUR

T1 - ent-Abietane diterpenoids from Isodon rubescens var. rubescens

AU - Huang, Sheng Xiong

AU - Pu, Jian Xin

AU - Xiao, Wei Lie

AU - Li, Li Mei

AU - Weng, Zhi Ying

AU - Zhou, Yan

AU - Han, Quan Bin

AU - Peng, Shu Lin

AU - Ding, Li Sheng

AU - Lou, Li Guang

AU - Sun, Han Dong

N1 - Funding Information: This work was financially supported by the Natural Science Foundation of Yunnan Province (No. 2004C0008Z) and by the National Natural Science Foundation of China (No. 20502026 to Q.-B. Han.). The authors were grateful to Mrs. Xu Zou for collecting the plant material.

PY - 2007/3

Y1 - 2007/3

N2 - ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC50 value of 0.91 μM against A549 cells.

AB - ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC50 value of 0.91 μM against A549 cells.

KW - Cytotoxicity

KW - Diterpenoid

KW - ent-Abietane

KW - Hebeiabinin

KW - Isodon rubescens var. rubescens

KW - Labiatae

UR - https://www.scopus.com/pages/publications/33847074637

U2 - 10.1016/j.phytochem.2006.11.007

DO - 10.1016/j.phytochem.2006.11.007

M3 - Journal article

SN - 0031-9422

VL - 68

SP - 616

EP - 622

JO - Phytochemistry

JF - Phytochemistry

IS - 5

ER -

ent-Abietane diterpenoids from Isodon rubescens var. rubescens

Abstract

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