ent-Abietane diterpenoids from Isodon rubescens var. rubescens

Sheng Xiong Huang, Jian Xin Pu, Wei Lie Xiao, Li Mei Li, Zhi Ying Weng, Yan Zhou, Quan Bin Han, Shu Lin Peng, Li Sheng Ding, Li Guang Lou, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

27 Citations (Scopus)

Abstract

ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC50 value of 0.91 μM against A549 cells.

Original languageEnglish
Pages (from-to)616-622
Number of pages7
JournalPhytochemistry
Volume68
Issue number5
DOIs
Publication statusPublished - Mar 2007

Scopus Subject Areas

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

User-Defined Keywords

  • Cytotoxicity
  • Diterpenoid
  • ent-Abietane
  • Hebeiabinin
  • Isodon rubescens var. rubescens
  • Labiatae

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