ent-Abietane diterpenoids from Isodon rubescens var. rubescens

Sheng Xiong Huang; Jian Xin Pu; Wei Lie Xiao; Li Mei Li; Zhi Ying Weng; Yan Zhou; Quan Bin Han; Shu Lin Peng; Li Sheng Ding; Li Guang Lou; Han Dong Sun

doi:10.1016/j.phytochem.2006.11.007

ent-Abietane diterpenoids from Isodon rubescens var. rubescens

Sheng Xiong Huang, Jian Xin Pu, Wei Lie Xiao, Li Mei Li, Zhi Ying Weng, Yan Zhou, Quan Bin Han, Shu Lin Peng, Li Sheng Ding, Li Guang Lou, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC₅₀ value of 0.91 μM against A549 cells.

Original language	English
Pages (from-to)	616-622
Number of pages	7
Journal	Phytochemistry
Volume	68
Issue number	5
DOIs	https://doi.org/10.1016/j.phytochem.2006.11.007
Publication status	Published - Mar 2007

Scopus Subject Areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

User-Defined Keywords

Cytotoxicity
Diterpenoid
ent-Abietane
Hebeiabinin
Isodon rubescens var. rubescens
Labiatae

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10.1016/j.phytochem.2006.11.007

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@article{10270716afff447c965cdb44eb8cf478,

title = "ent-Abietane diterpenoids from Isodon rubescens var. rubescens",

abstract = "ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC50 value of 0.91 μM against A549 cells.",

keywords = "Cytotoxicity, Diterpenoid, ent-Abietane, Hebeiabinin, Isodon rubescens var. rubescens, Labiatae",

author = "Huang, {Sheng Xiong} and Pu, {Jian Xin} and Xiao, {Wei Lie} and Li, {Li Mei} and Weng, {Zhi Ying} and Yan Zhou and Han, {Quan Bin} and Peng, {Shu Lin} and Ding, {Li Sheng} and Lou, {Li Guang} and Sun, {Han Dong}",

note = "Funding Information: This work was financially supported by the Natural Science Foundation of Yunnan Province (No. 2004C0008Z) and by the National Natural Science Foundation of China (No. 20502026 to Q.-B. Han.). The authors were grateful to Mrs. Xu Zou for collecting the plant material.",

year = "2007",

month = mar,

doi = "10.1016/j.phytochem.2006.11.007",

language = "English",

volume = "68",

pages = "616--622",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd.",

number = "5",

}

TY - JOUR

T1 - ent-Abietane diterpenoids from Isodon rubescens var. rubescens

AU - Huang, Sheng Xiong

AU - Pu, Jian Xin

AU - Xiao, Wei Lie

AU - Li, Li Mei

AU - Weng, Zhi Ying

AU - Zhou, Yan

AU - Han, Quan Bin

AU - Peng, Shu Lin

AU - Ding, Li Sheng

AU - Lou, Li Guang

AU - Sun, Han Dong

N1 - Funding Information: This work was financially supported by the Natural Science Foundation of Yunnan Province (No. 2004C0008Z) and by the National Natural Science Foundation of China (No. 20502026 to Q.-B. Han.). The authors were grateful to Mrs. Xu Zou for collecting the plant material.

PY - 2007/3

Y1 - 2007/3

N2 - ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC50 value of 0.91 μM against A549 cells.

AB - ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC50 value of 0.91 μM against A549 cells.

KW - Cytotoxicity

KW - Diterpenoid

KW - ent-Abietane

KW - Hebeiabinin

KW - Isodon rubescens var. rubescens

KW - Labiatae

UR - http://www.scopus.com/inward/record.url?scp=33847074637&partnerID=8YFLogxK

U2 - 10.1016/j.phytochem.2006.11.007

DO - 10.1016/j.phytochem.2006.11.007

M3 - Article

SN - 0031-9422

VL - 68

SP - 616

EP - 622

JO - Phytochemistry

JF - Phytochemistry

IS - 5

ER -

ent-Abietane diterpenoids from Isodon rubescens var. rubescens

Abstract

Scopus Subject Areas

User-Defined Keywords

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