Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites

Ken Cham Fai Leung; Chun Pong Chak; Siu Fung Lee; Josie M.Y. Lai; Xiao Ming Zhu; Yi Xiang J. Wang; Kathy W.Y. Sham; Christopher H.K. Cheng

doi:10.1039/c2cc36663k

Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites

Ken Cham Fai Leung^*
, Chun Pong Chak
, Siu Fung Lee
, Josie M.Y. Lai
, Xiao Ming Zhu
, Yi Xiang J. Wang
, Kathy W.Y. Sham
, Christopher H.K. Cheng

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

18 Citations (Scopus)

Abstract

Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8–10 nm), circular plasmid DNA (∼4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration.

Original language	English
Pages (from-to)	549-551
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	6
DOIs	https://doi.org/10.1039/c2cc36663k
Publication status	Published - 2013

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@article{746280751db947bfbb741495ee892f1c,

title = "Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites",

abstract = "Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8–10 nm), circular plasmid DNA (∼4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration.",

author = "Leung, \{Ken Cham Fai\} and Chak, \{Chun Pong\} and Lee, \{Siu Fung\} and Lai, \{Josie M.Y.\} and Zhu, \{Xiao Ming\} and Wang, \{Yi Xiang J.\} and Sham, \{Kathy W.Y.\} and Cheng, \{Christopher H.K.\}",

note = "We acknowledge the financial support by HKBU-FRG (FRG1/11-12/031) and AoE/P-03/08 research grants as well as the zeta-potential measurements conducted at The School of Chinese Medicine, HKBU.",

year = "2013",

doi = "10.1039/c2cc36663k",

language = "English",

volume = "49",

pages = "549--551",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "6",

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TY - JOUR

T1 - Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites

AU - Leung, Ken Cham Fai

AU - Chak, Chun Pong

AU - Lee, Siu Fung

AU - Lai, Josie M.Y.

AU - Zhu, Xiao Ming

AU - Wang, Yi Xiang J.

AU - Sham, Kathy W.Y.

AU - Cheng, Christopher H.K.

N1 - We acknowledge the financial support by HKBU-FRG (FRG1/11-12/031) and AoE/P-03/08 research grants as well as the zeta-potential measurements conducted at The School of Chinese Medicine, HKBU.

PY - 2013

Y1 - 2013

N2 - Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8–10 nm), circular plasmid DNA (∼4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration.

AB - Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8–10 nm), circular plasmid DNA (∼4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration.

UR - https://www.scopus.com/pages/publications/84871258613

U2 - 10.1039/c2cc36663k

DO - 10.1039/c2cc36663k

M3 - Journal article

C2 - 23192002

AN - SCOPUS:84871258613

SN - 1359-7345

VL - 49

SP - 549

EP - 551

JO - Chemical Communications

JF - Chemical Communications

IS - 6

ER -

Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites

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